Structure of PDB 7m5c Chain O Binding Site BS01

Receptor Information
>7m5c Chain O (length=151) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEQVAQDTEEVFRSYVFYRHQQEQEADPEMVTLPSSTMGQVGRQLAIIGD
DINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLG
FGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRGGWVAALNL
C
Ligand information
>7m5c Chain P (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SSTMGQVGRQLAIIGDDINRRY
Receptor-Ligand Complex Structure
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PDB7m5c Structural basis of BAK activation in mitochondrial apoptosis initiation.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		D84 I85 R88 Y89 E92 F93 M96 H99 I114 S117 L118 N124 G126 R127 L183
Binding residue
(residue number reindexed from 1)		D51 I52 R55 Y56 E59 F60 M63 H66 I81 S84 L85 N91 G93 R94 L150
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7m5c, PDBe:7m5c, PDBj:7m5c
PDBsum7m5c
PubMed35017502
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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