Structure of PDB 7m4v Chain O Binding Site BS01

Receptor Information

>7m4v Chain O (length=116) Species: 480119 (Acinetobacter baumannii AB0057)

GKHPLVQAIENSQLKTDLPEFAPGDTVVVQVKVKEGDRERLQAFEGVVIA
KKNRGLNSAFTVRKISSGVGVERVFQTHSPVVAKIEVKRRGDVRRAKLYY
LRDLSGKAARIREKLP

Ligand information

>7m4v Chain A (length=2732)

agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgau
gaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuu
ugauccggagaugucugaaugggggaacccaccuacuuuaagguagguau
ugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacau
cucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcg
agcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcuc
ugggaagugcgaacguagagggugauauucccguacacgaaagggcacac
auaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggg
gggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccag
uaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagau
ccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacug
cguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaa
ccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguug
cuggguauagacccgaaaccaggcgaucuauccaugagcagguugaaggu
uggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggg
gaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugg
uucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggg
uagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacua
uccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaa
uccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaug
ugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaa
cggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgug
guaggggagcguucuguaagccgaugaagguguguugagaagcaugcugg
agguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaa
aacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcu
gggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaa
ugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaagg
cuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguau
cuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguac
uugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcu
ucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgag
uagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaauggu
accguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuc
cugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaa
aacauagcacucugcaaacacgaaaguggacguauagggugugaugccug
cccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuuga
ucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcg
aaauuccuugucggguaaguuccgaccugcacgaauggcauaaugauggc
ggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugaagaug
caguguacccgcggcuagacggaaagaccccgugaaccuuuacugcagcu
ugacacugaacuuugauugagguucuaacucugucccgugauccgggacg
aggaccgugucugguggguaguuugacuggggcggucuccuccuaaagag
uaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguag
aguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagg
uacgaaaguaggucuuagugauccggugguucuguauggaagggccaucg
cucaacggauaaaagguacucuggggauaacaggcugauaccgcccaaga
guucauaucgacggcgguguuuggcaccucgaugucggcucaucucaucc
uggggcugaagcaggucccaaggguauggcuguucgccauuuaaagaggu
acgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccg
ugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagag
uggacgaaccucugguguaccgguugugacgccagucgcaucgccgggua
gcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuac
cucaagauaagauuucccuaggacuuuauguccucuaaagagccguucga
gacuaggacguugauagguuggauguggaagcauagugauaugugaagcu
gaccaauacuaauugcucgugaggcuugacua

<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<...
...<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))...]..>>..
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>
>......>>>>>.>.........<<....>>...<<<<<.....<<....
.>>....>>>>>...<<<...<..<<<<<<<<<<<<<<.<<<...<<<.<
......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>
>>>>>...>.......<<<<<<<<.........>>>>>>>>......<<<
<<..<<<<>>>>>..>>>......]].>>>>>>>.]].............
..<<....>>....]].........<<<<.....>>>>............
......>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>
>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...
<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>
>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<
<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>
>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>
..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<...
..<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...
>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......
>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<
<<<<..<<........<<<..>>>....>>..>>>>>.>>..........
.)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>.
...>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>..
.>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.....
..>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>
>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<
<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<
<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<
<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<..
....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>.
...>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<...
..>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<
<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>
>...>>>>>>>>>>>>............<<<<<<<<<..<<<........
.>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<
<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>...
....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>
>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........
>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<
.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>
>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<.......
....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....
.<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.
<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>
.............>>>>..]]>>>>.......<<<<...<<<<<<...<<
.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<
<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>
..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>
>>>>....<<<<<<<...<<<<..<<<<<<.................>>>
>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...
>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>
>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<..
.....>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>.
..>>>>>.>>>...>>>>..>..>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7m4v Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii.
• Resolution: 2.54 Å
• Binding residue (original residue number in PDB): K4 H5 K54 N55 R56 N59 Q78 R96 R97 A98 K99 Y101 Y102
• Binding residue (residue number reindexed from 1): K2 H3 K52 N53 R54 N57 Q76 R94 R95 A96 K97 Y99 Y100

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7m4v, PDBe:7m4v, PDBj:7m4v
• PDBsum: 7m4v
• PubMed: 34044590
• UniProt: B7IAS9|RL19_ACIB5 Large ribosomal subunit protein bL19 (Gene Name=rplS)