Structure of PDB 7a5j Chain O Binding Site BS01

Receptor Information
>7a5j Chain O (length=152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEK
LIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRML
QIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQ
SQ
Ligand information
>7a5j Chain A (length=1492) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaau
agggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuua
accagugaaauugaccugcccgugaagaggcgggcauaacacagcaagac
gagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaa
acccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuauucuagaguccauaucaacaauag
gguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcua
uuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucag
accggaguaauccaggucgguuucuaucuacuuuauuccucccuguacga
aaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaau
gauaucaucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<..............<....<<<.........>>>....>.....
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>>..
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
>...<<........>>...........<...........<<<<<<.....
>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>
>>>.>>...........<<<<<........>>>>>.......<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............
<<<....>>>................>>>>>>>>>>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>...........<....>..............>>>>
..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>
>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>
>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<
<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.........
........>>>.>>><<<<<...<<<....>>>.>>>>>......<<<..
..............>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a5j Elongational stalling activates mitoribosome-associated quality control.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		I9 S10 H11 G12 R13 V14 R16 R17 L20 G21 P22 H27 N31 H39 I42 E43 A47 R48 T81 E82 L115 D116
Binding residue
(residue number reindexed from 1)		I1 S2 H3 G4 R5 V6 R8 R9 L12 G13 P14 H19 N23 H31 I34 E35 A39 R40 T73 E74 L107 D108
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5j, PDBe:7a5j, PDBj:7a5j
PDBsum7a5j
PubMed33243891
UniProtQ9NRX2|RM17_HUMAN Large ribosomal subunit protein bL17m (Gene Name=MRPL17)

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