Structure of PDB 7a18 Chain O Binding Site BS01

Receptor Information

>7a18 Chain O (length=98) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

MFAIIQTGGKQARVSEGDVIRVESLQGEAGDKVELKALFVGGEQTVFGED
AGKYTVQAEVVEHGRGKKIYIRKYKSGVQYRRRTGHRQNFTAIKILGI

Ligand information

>7a18 Chain X (length=2699)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaac
cgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcugg
aaagcuacaccucagaaggugagaguccuguaggcgaacgagcccugagu
aggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaa
ggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggu
gaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuua
caagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaug
agccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcg
gagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacuc
gaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggagg
accgaaccggugccugcugaaacagucucggaugaguuguguuuaggagu
gaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauuga
gguacagccucggauguugaccauguccuguagagcacucacaaggcuaa
aaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcug
cgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcua
aggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagaca
gccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagc
ucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucu
accgaagcuauggauucaacucggaguugucugguaggggagcguucagu
ccgcggagaagccauaccggaaggagugguggagccgacugaagugcgga
ugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaagg
acaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaa
ggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcac
cgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcu
auggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuac
cggucugccucagacguaucgggagccgaaguuggaaacgcgacggugcc
aagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgac
acagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguua
aggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgc
ugcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacag
cacucugccaacacgaacaguggacguauagggugugacgccugcccggu
gccggaaggucaaguggagcggugcaagcugcgaaaugaagccccgguga
acggcggccuaagguagcgaaauuccuugucggguaaguuccgaccugca
cgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaau
ugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagacccc
guggagcuuuacuauagucuggcauugggauucggguuucuagaaacuug
gauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguu
ugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucac
cucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuu
gacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaac
cggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccg
gggauaacaggcugaucucccccgagaguccauaucggcggggagguuug
gcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaagg
guugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacguc
gugagacaguucggucucuauccgcuacgggcgcaggagaauugagggga
guugcuccuaguacgagaggaccggagugaacggaccgcuggucucccug
cugucguaccaacggcacaugcaggguagcuauguccggaacggauaacc
gcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacug
aagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgc
auagcaauguguucagcggacuggugcucaucagucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<......>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<....<
<<<<<<<....>>>>>>>>......<<<....<<..<<<...<<<<<...
...>>>>>((......<<<.....))>>>...>>>....>>..>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..
>>>......>>.>>>>>>.>>..............<<....>>....>>.
........<<<<....>>>>..................>>>>>>>>>>>.
......<<<<<<<<<<.......>>>>>>>>>>...<............>
.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>.
..<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.
<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......
>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<
.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<...
.>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<....
..>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<
<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<<<<<<........
<<<<<.<<.....<.........>.....>>..........<......>.
...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.
>>>...>>>>>>><..<<<<<...>>>>>..>....>>>>>><.<<<<<<
<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>....
.>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...
<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))
<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<.
..[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>
>>>>>.>>>>..>>>>>>>>>..........>>>>>...>>>...>>>>.
........>>>>...>>......>>>>>>>>>>>>>..>>.....<<...
...>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<....<....>.....>>>>><<<<<<<<
.>>>>>>>>............<<<<<<<<<..<<...........>>..<
<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<
<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..
>>>>>...........<...........<<<<<<.....>>>>>>.....
>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....
>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<
<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<<......>>>..>
>>>>>>...<<<<<<.......>>.>>>>....>>>>>.>>>..>>>>>.
.<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>.
..<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......
<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>
>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>
>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>
>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<.
.<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<
<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<
<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.
.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<
<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a18 Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): Q6 T7 V22 R65 G66 K67 K68 Y70 I71 Y74 K75 G77 V78 Q79 Y80 R81 R82 R83 G85 H86 R87 Q88 N89 F90
• Binding residue (residue number reindexed from 1): Q6 T7 V22 R65 G66 K67 K68 Y70 I71 Y74 K75 G77 V78 Q79 Y80 R81 R82 R83 G85 H86 R87 Q88 N89 F90

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7a18, PDBe:7a18, PDBj:7a18
• PDBsum: 7a18
• PubMed: 34417608
• UniProt: Q9RY64|RL21_DEIRA Large ribosomal subunit protein bL21 (Gene Name=rplU)