Structure of PDB 6zxf Chain O Binding Site BS01

Receptor Information
>6zxf Chain O (length=126) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAM
LAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMK
IGRIEDVTPIPSDSTRRKGGRRGRRL
Ligand information
>6zxf Chain 2 (length=1656) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcgc
ggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgc
cgugccuaccauggugaccacgggugacggggaaucaggguucgauuccg
gagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgc
gcaaauuacccacucccgacccggggagguagugacgaaaaauaacaaua
caggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuu
uaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauu
ccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguagu
uggaucucucucggccgaagcguuuacuuugaaaaaauuagaguguucaa
agcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcggu
ucucggaacugaggccaugauuaagagggacggccgggggcauucguauu
gcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcga
aagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguu
cgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccg
gcgaugcggcggcguuauaugacccgccgggcagcuuccgggaaaccaaa
gucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaa
uugacggaagggcaccaccaggaguggagccugcggcuuaauuugacuca
acacgggaaaccucacccggcccggacacggacaggauugacagauugau
agcucuuucucgauuccgugggugguggugcauggccguucuuaguuggu
ggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcu
aacuaguuacgcgacccccggucggcguaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucg
cuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggg
gugcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu
aacgga
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<.<....<<....<<<<..........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<..........>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<..>
>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<....
.....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>
.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>..
.......<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<
<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>
..>>.........<<<<<((......<<<<.....<<..))>>.......
>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<
<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<......
.>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<
<<...>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<
<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<..
..>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...
<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<
<<..<.<<<<<<.<<<<<>>>>>>>>>>>.>..>>>...<<..))>>...
>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).
]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<.....
...>>..........<<<<<.<....<<<<<<.......<<.<<<.....
...>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<
<<......>>...<<<......>>>...>>.>>>....<<<...<...<<
<<..<<<<<<<<<<<<...>>>>.>>>>>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>.........<<.
<<<<<..........>>>>>>>.........>>>>>.....<<<<<<<<.
......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
.<<<<.<<.....<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<.<<<
<..>>>>.>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>....>>.
>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........
......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zxf Structural basis for the final steps of human 40S ribosome maturation.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		N38 D39 H43 G49 K50 T52 R55 T57 G59 M60 D65 R66 E68 R98 I135 P136 S137 D138 T140 R141 K143 R146 R147 R149 R150
Binding residue
(residue number reindexed from 1)		N13 D14 H18 G24 K25 T27 R30 T32 G34 M35 D40 R41 E43 R73 I110 P111 S112 D113 T115 R116 K118 R121 R122 R124 R125
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zxf, PDBe:6zxf, PDBj:6zxf
PDBsum6zxf
PubMed33208940
UniProtP62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)

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