Structure of PDB 6zxe Chain O Binding Site BS01

Receptor Information
>6zxe Chain O (length=135) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADR
DESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSAL
RALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
Ligand information
>6zxe Chain 2 (length=1645) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucgucguaguuccgaccauaaa
cgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcag
cuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaag
cugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugc
ggcuuaauuugacucaacacgggaaaccucacccggcccggacacggaca
ggauugacagauugauagcucuuucucgauuccgugggugguggugcaug
gccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaac
gagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuua
gagggacaaguggcguucagccacccgagauugagcaauaacaggucugu
gaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucag
cgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauu
cgugauggggaucggggauugcaauuauuccccaugaacgaggaauuccc
aguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguac
gucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgc
cggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuag
aggaaguaaaagucguccguagguccugcggaaggaucauuaacg
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>
>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<..>>>>...>>>>>>>>......
....<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>
>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>
>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<..<<<.<<<
<........<<........>>..........<<<<<.<....<<<<<<..
.....<<..<<........>>..>>.....>>>>>>...<<.<<<..<<<
<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>
....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>
>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>
.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<.....
...........<<<.<<<<....>>>>.>>>..............>>>.>
>............<<<<<..........>>>>>...........>>>>>.
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..
<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<
<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>..
.>>.>>>>...>.>.<<<<<<<<.>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zxe Structural basis for the final steps of human 40S ribosome maturation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		F37 N38 D39 F41 H43 G49 K50 T52 R55 T57 G59 M60 D65 R66 R98 P134 I135 P136 S137 D138 R141 K143 R146 R149
Binding residue
(residue number reindexed from 1)		F21 N22 D23 F25 H27 G33 K34 T36 R39 T41 G43 M44 D49 R50 R82 P118 I119 P120 S121 D122 R125 K127 R130 R133
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zxe, PDBe:6zxe, PDBj:6zxe
PDBsum6zxe
PubMed33208940
UniProtP62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)

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