Structure of PDB 6rie Chain O Binding Site BS01

Receptor Information
>6rie Chain O (length=822) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDANVVSFSTIATYIDALAKNASELEQRSTAYEINNELELVFIKPPLITL
TNVVNISTIQESFIRFTVTNKEGVKIRTKIPLSKVHGLDVKNVQLVDAID
NIVWEKKSLVTENRLHKECLLRLSTEERHIFLDYKKYGSSIRLELVNLIQ
AKTKNFTIDFKLKYFLGSGAQSKSSLLHAINHPKSRPNTSLEIEFTPRDN
ETVPYDELIKELTTLSRHIFMASPENVILSPPINAPIKTFMLPKQDIVGL
DLENLYAVTKTDGIPITIRVTSNGLYCYFTHLGYIIRYPVKRIIDSEVVV
FGEAVKDKNWTVYLIKLIENDRLEESKYVESKLVDICDRIVFKSKKYEGP
FTTTSEVVDMLSTYLPKQPEGVILFYSKGPKSNIDFKIKKENTIDQTANV
VFRYMSSEPIIFGESSIFVEYKKFSNDKGFPKEYGSGKIVLYNGVNYLNN
IYCLEYINTHNEVGIKSVVVPIKFIAEFLVNGEILKPRIDKTMKYINSED
YYGNQHNIIVEHLRDQSIKIGDINDKFRLNPEVSYFTNKRTRGPLGILSN
YVKTLLISMYCSKTFLDDSNKRKVLAIDFGNGADLEKYFYGEIALLVATD
PDADAIARGNERYNKLNSKTKYYKFDYIQETIRSDTFVSSVREVFYFGKF
NIIDWQFAIHYSFHPRHYATVMNNLSELTASGGKVLITTMDGDKLSKLTD
KKTFIIHKNLPSSENYMSVEKIADDRIVVYNPSTMSTPMTEYIIKKNDIV
RVFNEYGFVLVDNVDFATIIERSKKFINGASTMEDRPSTKNFFELNRGAI
KCEGLDVEDLLSYYVVYVFSKR
Ligand information
Receptor-Ligand Complex Structure
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PDB6rie Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E39 I43 K75 R77 K107 R122 R142 K161 F165 E192
Binding residue
(residue number reindexed from 1)		E39 I43 K75 R77 K107 R122 R142 K161 F165 E192
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.7.7.50: mRNA guanylyltransferase.
3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004484 mRNA guanylyltransferase activity
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008168 methyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0050355 inorganic triphosphate phosphatase activity
GO:0140818 mRNA 5'-triphosphate monophosphatase activity
Biological Process
GO:0006353 DNA-templated transcription termination
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rie, PDBe:6rie, PDBj:6rie
PDBsum6rie
PubMed31835031
UniProtP04298|MCEL_VACCW mRNA-capping enzyme catalytic subunit (Gene Name=OPG113)

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