Structure of PDB 6nqb Chain O Binding Site BS01

Receptor Information

>6nqb Chain O (length=86) Species: 562 (Escherichia coli)

LSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHS
RRGLLRMVSQRRKLLDYLKRKDVARYTRLIERLGLR

Ligand information

>6nqb Chain A (length=1341)

ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacac
augcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgagug
gcggacgggugaguaaugucugggaaacugccugauggagggggauaacu
acuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagaggggg
accuucgggccucuugccaucggaugugcccagaugggauuagcuaguag
gugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggau
gaccagccacacuggaacugagacacgguccagacuccuacgggaggcag
caguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcg
uguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagg
gaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcacc
ggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaa
ucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaug
ugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuug
agucucguagagggggguagaauuccaggaauaccgguggcgaaggcggc
ccccuggacgaagacugacgcucaggugcgaaagcguggggagcauaguc
cacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuu
ccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguu
aaaacucaaaugaauugacgggggcccgcacaagcgguggagcauguggu
uuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaa
guuuucagagaugagaaugugccuucgggaaccgugagacaggugcugca
uggcugucgucagcucguguugugaaauguuggguuaagucccgcaacga
gcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaagga
gacugccagugauaaacuggaggaagguggggaugacgucaagucaucau
ggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagag
aagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccgg
auuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgug
gaucagaaugccacggugaauacguucccgggccuuguaca

....<<<<..[[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>
>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<
<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<.
.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<
<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>
...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>
>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.
.<<<<......<<<<....>>>>.....>>>>.....<<<<<......<.
<<<<<<.<.......>.>>>>>>.>........>>>>>.......<<<<<
(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>
>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<
<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...
<<<<<<<<...<<<<.<.....<<..>>...........<<....>>...
>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<<........>>
>>>>>..........<<<<<<..<<<<<<.<<<<<.....>>>>>.>>>>
>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>
....>>>..)))).]].<<<.<<<<<<<..<..<<<<....<<<<<<<<<
............................<<<<<<<........<<<<<..
.<<<<<<....>>>>>>....<<....>>..>>>>>.....<<.<<<...
<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>
>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>
.....<<<<<.....>>>>>........>>>>.......>.>>>...>>.
>>>>>....>>>>>>>...>>.>>>>>>>........<<<<......<<<
..<<...<<<....>>>...>>....>>>......>>>>...........
....<<<............>>>.............>>>>.....<<<<<<
<.........>>>>>>>......>....>>>>>>>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6nqb Role of Era in assembly and homeostasis of the ribosomal small subunit.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): L2 S3 D20 Q27 L38 H41 H45 K47 D48 H49 H50 S51 R53 K64 Y68 R71 K72
• Binding residue (residue number reindexed from 1): L1 S2 D19 Q26 L37 H40 H44 K46 D47 H48 H49 S50 R52 K63 Y67 R70 K71

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0006417 regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6nqb, PDBe:6nqb, PDBj:6nqb
• PDBsum: 6nqb
• PubMed: 31265110
• UniProt: P0ADZ4|RS15_ECOLI Small ribosomal subunit protein uS15 (Gene Name=rpsO)