Structure of PDB 6g18 Chain O Binding Site BS01

Receptor Information

>6g18 Chain O (length=135) Species: 9606 (Homo sapiens)

LGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADR
DESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSAL
RALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

Ligand information

>6g18 Chain 2 (length=1658)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucagauaccgucguaguuccga
ccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgc
cgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguauggu
ugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggcuuaauuugacucaacacgggaaaccucacccggcccggac
acggacaggauugacagauugauagcucuuucucgauuccguggguggug
gugcauggccguucuaguugguggagcgauuugucugguuaauuccgaua
acgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaac
uucuuagagggacaaguggcguucagccacccgagauugagcaauaacag
gucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacug
gcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauu
cgugauggggaucggggauugcaauuauuccccaugaacgaggaauuccc
aguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguac
accgcgucgcuacuaccgauuggaugguuuagugaggcccucggaucggc
cccgccggggugcccuggcggagcgcugagaagacggucgaacuugacua
ucuagaggaaguaaaagucggguuuccguaggugaaccugcggaaggauc
auuaacgg

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((....<.<<<<.....<<..))>>..
.....>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>
>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>
>>.>..>>>...<<.)).>>...>>.....>>>.>.>.<<<......<<<
<....>>>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<..
<<<.<<<<<<............................<<<<<.<....<
<<<<<.......<<.<<<........>>>.>>.....>>>>>>......<
<<<<<<<<<<<<<...<<<.<<<<<....>>>...<<<......>>>...
>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>
>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>
>>>.>>>.>>>>.......>.>>>>>...>>.>>>>.>>>.....<<.<<
<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>
>......<.....<<<<<..........>>>>>.....>.....>>>>>.
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..
<<<.<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<
<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>
>>>...>>.>>>>...>.>>>>><<<<<<<<<....>>>>>>>>>.....
........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g18 Visualizing late states of human 40S ribosomal subunit maturation.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): F37 N38 D39 F41 H43 G49 K50 E51 T52 R55 T57 G59 D65 R66 E68 R98 P136 S137 D138 T140 R141 K143 R146 R149 L151
• Binding residue (residue number reindexed from 1): F21 N22 D23 F25 H27 G33 K34 E35 T36 R39 T41 G43 D49 R50 E52 R82 P120 S121 D122 T124 R125 K127 R130 R133 L135

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0045182 translation regulator activity
• GO:0048027 mRNA 5'-UTR binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0006417 regulation of translation
• GO:0030218 erythrocyte differentiation
• GO:0030490 maturation of SSU-rRNA
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0014069 postsynaptic density
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6g18, PDBe:6g18, PDBj:6g18
• PDBsum: 6g18
• PubMed: 29875412
• UniProt: P62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)