Structure of PDB 6c0f Chain O Binding Site BS01

Receptor Information
>6c0f Chain O (length=184) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEPVVVIDGKGHLVGRLASVVAKQLLNGQKIVVVRAEELNISGEFFRNKL
KYHDFLRFRAPSRIFYKALRGMVSHKTARGKAALERLKVFEGIPPPYDKK
KRVVVPQALRVLRLKPGRKYTTLGKLSTSVGWKYEDVVAKLEAKRKVSSA
EYYAKKRAFTKKVASANATAAESDVAKQLAALGY
Ligand information
>6c0f Chain 1 (length=1357) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaaaagcggaggaaaaga
aaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaa
auuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaa
cuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagg
gugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucga
agagucgaguuguuuugcagcucuaagugggugguaaauuccaucuaaag
cuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagau
gaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagg
gaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggg
uaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggau
aaauccauaggaauguagcuugccucgguaaguauuauagccugugggaa
uacugccagcugggacugaggacugcgacguaagucaaggaugcuggcau
aaugguuauaugccgcggaccaaggagucuaacgucuaugcgaguguuug
gguguaaaacccauacgcguagguuggggccucgcaagaggugcacaauc
gaccgauccugaugucuucggauggauuugaguaagagcauagcuguugg
gacccugguuccugccgaagaacguagaguuaaggugccggaauacacgc
ucaucagaggcgcucaagcguguuaccuauacucuaccgucaggguugau
augaugcccugacgaguaggcaggcguggaggucagugacgaagccuaga
ccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagc
aaauugauagaauaaucuagcgaaaccaauguuaccgcaauaguaauuga
acuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugu
gcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaag
ucagaauccaugcuagaacgcggugaucuccacacaauauagauggauac
gaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggu
gcacuuggcggaaaggccuugggugcuugcuggcgaauugcaauggcgug
gggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagc
aguagaguagccuuguuguuacgaucugcugagauuaagccuuuguuguc
ugauuug
..........................<<<<<<....>>>>>.>.......
..<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<
........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.
<<<.<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<
<......)>>>..>.>>>>>>>>>..>>>>>>>.....>>>>>>>>>>..
......<<<<<<<...>>>>>>>.....<<<<<<......>>>>>>..>>
>..................................<<....>>.......
........<<<......>>>..............................
....<<<<<.<<<<<<.....<<<<...<<<<.<<<<<<<<<.....>>>
>>>>>>.....>>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<...
..<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>>..
>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>..
..>>>>>>.>>>>>....<<<<<<....<<<<<<.<<<<<<..<<<...<
<<<.....>>>>...>>>...<<<<<..<<<<<....>>>>>...>>>>>
.<<<<<<<<...<......>...>>>>.>>.>>....>>>>>>.>>>>>>
..<<..>>..<<<<<<.......<<<<<<<..<<<<(((.....<<<<<<
.....<<.))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<....
.....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<
<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<.
.......<<<<....>>>>.>....>>....<<<<<<<..<<<<...<<<
<<<...............>>>>>>..<<<<<...<<<<<<<.<<<<<.<.
.>...>>>>>>>>>>>>..>>>>>.<<<<...<<<<<...........>>
>>>...>>>>.>>>>....>>>>>>>.<<<<<<.<.........<<....
......<<<<<<.....>>>>>>......>>.......<<<<<<...<<<
<<.<..<<<......>>>..>.>>>>>.>>>>>>...........>.>>>
>>>.<<<<<<.<.............>.....<<<<<<<<<.<<<....<<
<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.
.>>>>>>
Receptor-Ligand Complex Structure
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PDB6c0f Modular assembly of the nucleolar pre-60S ribosomal subunit.
Resolution3.7 Å
Binding residue
(original residue number in PDB)
P5 V6 V8 K12 G17 R18 S21 K25 K32 R37 S44 E46 F48 R49 D56 R74 K82 A83 G86 M87 T92 A93 R101 F105 G107 I108 P109 Y112 D113 K114 K115 K116 R117 Q122 R128 L129 K130 P131 R133 S144 G146 Y149 L156 E157 K161 S164 Y167 Y168 K171 R172 K176
Binding residue
(residue number reindexed from 1)
P3 V4 V6 K10 G15 R16 S19 K23 K30 R35 S42 E44 F46 R47 D54 R59 K67 A68 G71 M72 T77 A78 R86 F90 G92 I93 P94 Y97 D98 K99 K100 K101 R102 Q107 R113 L114 K115 P116 R118 S129 G131 Y134 L141 E142 K146 S149 Y152 Y153 K156 R157 K161
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000470 maturation of LSU-rRNA
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6c0f, PDBe:6c0f, PDBj:6c0f
PDBsum6c0f
PubMed29512650
UniProtP26784|RL16A_YEAST Large ribosomal subunit protein uL13A (Gene Name=RPL16A)

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