Structure of PDB 6az1 Chain O Binding Site BS01

Receptor Information
>6az1 Chain O (length=137) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAYGPNVKKGDLVYGVVHIYASFNDTFVHVTDTSGRETYVKVTGGMKVKA
DRDESSPYAAMMAAQDVVARCKECGINALHVKMRAVGGVRTKSPGPGAQA
ALRALARAGMKIGRIEDVTPIPTDSTRRKGSRRGRRL
Ligand information
>6az1 Chain 1 (length=1760) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaca
ucagacguaaucugccgcaaaaaucuugcgguccgcaaaauuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaccgggugucuccagagacg
cccagcgaaugaaugacaaaaccaaugccugcaguaacacccagcagugu
ugacucaauucauuccgugcgaaagccggcccggcgucuuuugacgaaca
acugcccuaucagcuggugauggccguguaguggacugccauggcguuga
cgggagcgggggauuaggguucgauuccggagagggagccugagaaauag
cuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaa
caaaacgaugaggcagcgaaaagaaauagaguuuucaaugggggauauuu
aaacccauccaauaucgaguaacaauuggaggacaagucuggugccagca
cccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaa
aggguucguaguugaacugugggcuguucccguccauucggaugacccug
cagcccgugaacagaaacaacgggagugggggcguccgugauuuuuuacu
gugacuaaagaagcgugacuaaagcagucaugacugaauuagaaagcaug
ggauaacaaaggagcaguuuuaaaggucuauuggagauuauggagcugug
cgacaagugcuuucccauaggaaugaaggaggguagucgggggagaacgu
acuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacag
cgaaggcauucuucaaggauaccuuccucaaucaagaaccaaagugugga
gaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacac
ccaugaauuggggauccuuacguaucuuucucagcacguuuucuguuuuc
acgcgaaagcuuugagguuacagucucaggggggaguacguucgcaagag
ugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcg
guuuaauuugacucaacacggggaacuuuaccagauccggacaggaugag
gauugacagauugaguguucuuucucgauucccugaaugguggugcaugg
ccgcuuuuggucgguggagugauuuguuugguugauuccgucaacggacg
agauccaagcugcccaguagaauucagaauugcccauaggauaggcauuc
gucgaauucuucucugcgggauuccuuguaaugcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaaaaacgagucgaaccuacuugaucaaaa
gaguggggaaaccccggaaucacauagacucacuugggaccgaggauugc
aauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaaac
ugugccgauuacgucccugccauuuguacacaccgcccgucguuguuucc
gaugauggugcaauacaggugaucggacgaaaguucaccgauauuucuuc
aauagaggaagcaaaagucguaacaagguagcuguaggugaaccugcagc
uggaucauuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
.<<<..<<..<<...<<.<<.....<<<<<<.>>>>>>...<<.....<<
<<<<.....>>>>>>......>>..........<<<<<<<<<..>>>>>>
>>>.<<<<<<<<<<.....((.{....<..>...................
.......>>>>>>>>...>>....<<<<<.>>>>>...>>.>>..>>>>.
.>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>.....
.>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>
>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<....
......>>>..>>>..>....>>>....<<<..>>>.....<<<<.....
.......>>>.....>.........<<<<<((....<.<<<<.....<<.
.))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[..
...<<<<...<<<..<....<...<<.<<....<......>..>>...>>
...>.........................................<<<<<
<<<.......<<...<.......>..<<<..>>>....>>......>>>>
>..>>>..........<<<.<..<<...<......}.))...>..>>..>
.>>>...................>......<<<<<.<<...<<<<<<<<.
.<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<
<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<
<...<..<.<<<<<..........<.<......>.>..>>>>>.>..>..
..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>
>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<
<<......<<........>>..........<<<<<......<<<<.....
....<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<
<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>.
...<<<<<.<<<<.....<<<<<<<.<<<<................>>>>
...>>>>>>>.....>>>>....<<<<<<.....>>>>>>.......>>>
>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<.....<<<.>>>..<<<<<<<........
>>>>>>>....>........>>>...>>>......<....<<<..<....
......>..>>>.....>.....>>>>>>....<<<<<<<.........>
>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<
..<<.<<<.<.<<<<..<<<<<.<........>.>>>>>..>>>>.>.>>
>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>
>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6az1 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N31 D32 F34 H36 S41 G42 R43 T45 T50 G52 M53 D58 R59 R91 G95 I128 P129 T130 D131 T133 R134 K136 G137 S138 R139 R140 R142 R143
Binding residue
(residue number reindexed from 1)		N24 D25 F27 H29 S34 G35 R36 T38 T43 G45 M46 D51 R52 R84 G88 I121 P122 T123 D124 T126 R127 K129 G130 S131 R132 R133 R135 R136
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az1, PDBe:6az1, PDBj:6az1
PDBsum6az1
PubMed29150609
UniProtA0A3S7X3Z7

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