Structure of PDB 5xxu Chain O Binding Site BS01

Receptor Information
>5xxu Chain O (length=129) Species: 5811 (Toxoplasma gondii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDGEIVFGVAHIYASFNDTFIHVTDLSGRETLVRVTGGMKVKADRDESSP
YAAMMAAADVAARCKELGISAVHVKVRAAGGTRKTPGPGAQSALRALARS
GLRIGRIEDVTPIPTDSTRRKSGRRGRRL
Ligand information
>5xxu Chain 2 (length=1619) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaccugguugauccugccaguagucauaugcuugucuuaaagauuaagcc
augcaugucuaaguauaagcuuuuauacggcuaaacugcgaauggcucau
uaaaacaguuauaguuuauuugauggucuacauggauaaccgugguaauu
cuauggcuaauaccugcgcacaguguuuauuagauacagaaccaagguga
uucauaguaaccgaacggaucgcgcugcgacggaucauucaaguuucuga
ccuaucagcuuucgacgguacuguaauggacuaccguggcagugacgggu
aacggggaauuaggguucgauuccggagagggagccugagaaacggcuac
cacaucuaaggaaggcagcaggcgcgcaaauuacccaauccugauucagg
gagguagugacaagaaauaacaaccuggagugauuggaugauaggaaucc
aaaccccuuucagaguaacaauuggagggcaagucuggugccagcagccg
cgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaag
cucguaguuggauuucugcuggaaggccaauucuagcauccuucuggacu
uuuacuuugagaaaauuagaguguuucaagcaggcuugucgccuugaaua
cucagcauggaauaauaagauuucggcccuauuuugguuucuaggacuga
aguaaugauuaauagggacgguugggggcauucguauuuaacugucagag
gugaaauucuuagauuuguuaaagacgaacuacugcgaaagcauuugcca
aagauguuuucauuaaucaagaacgaaaguuaggggcucgaagacgauca
gauaccgucguagucuuaaccauaaacuaugccgacuagagauaggaaaa
cgucaugacuucuccugcaccuuaugagaaaccaaagucuuuggguucug
gggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggca
ccaccaggcguggagccugcggcuuaauuugacucaacacggggaaacuc
accagguccagacauaggaauugacagauugauagcucuuucuugauucu
augggugguggugcauggccguucuuaguugguggagugauuugucuggu
uaauuccguuaacgaacgagaccuuaaccugcuaaauaggaucaggaacu
ucguguucuuguaucacuucuuagagggacuuugcgugucuaacgcaagg
aaguuugaggcaauaacaggucugugaugcccuuagauguucugggcugc
acgcgcgcuacacugaugcauccaacgaguccuuggccgauaggucuagg
uaaucuugugaguaugcaucgugauggggauagauuauugcaauuauuaa
ucuucaacgaggaaugccuaguaggcgcaagucagcacguugcgccgauu
acgucccugcccuuuguacacaccgcccgucgcuccuaccgauugagugu
uccggugaauuauucggaccguuuuguggcccgaaaugggaaguuuugug
aaccuuaacacuuagaggaaggagaagucguaacaagguuuccguaggug
aaccugcggaaggaucauu
...<<<<<.{.[[[[>>>>><<<..<<<<<<...<<<<..<......<<<
.<<<..<<....<<....<<<.......>>>...>>.>>......<<..<
.....<<<..<<..<<....<<<<.........<.....<<<<<<.....
>>>>>>......>.........<<..<<<<<<.......(((((......
....>>>>>>....>>...<<<<...>>>>...>>>>...>>>>..>>>.
<<<....<<<....<<<<<<...........>>>>>>>>>......>>>.
..<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>
>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>
..>>>..>...>>>>.....<<<.<....>...>>>.....<.<<<....
.......>>>.>.........<<<<<((....<.<<<<.....<<..))>
>.......>>>>>>>>>>..>>>>>>.>>>.........<<<[[.....<
.<<...<<<.<<.....<<<<<<<......>>>>>>>.....<...>...
.<<<<<.<<.......<<...<.......>..<<<.....>>>.....>>
.....>>.>>..>>>.....<<<<<<.<<<....)))))...>>>.>>>>
>>......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<
......>>>......>.>>>>>.>.>>.......<<....>>...>>>>.
..>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<.<.<<<<<.<<
.<<<..>>>>>.>>>>>..>>>...<...]].>...>>.....>>>.>>>
.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<
..<<.<<<<<<..<<<.<<<<<<......<<........>>.........
.<<<<<.<....<<<<<......<..<<........>>..>.......>>
>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<.
.....>>>...>>.>>>....<<<<<.<<..<<<<..<<....<<<<<<.
....>>>>>>......>>..>>>>.>>....<<<<<<.....>>>>>.>.
.....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>
.>>>>.>>>.....<<<<<<<......<<.<<<.<<<<....>>>>.>>>
....>>.......>>>>>>>...........<<<<<<..........>>>
>>>..........>>>>>>....<<<<<<<.........>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<
<..<<<..<<.<..<...<<<<<<<<.....>>>>>>>>...>..>.>>.
.>>>..>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB5xxu Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Resolution3.35 Å
Binding residue
(original residue number in PDB)		H37 N43 D44 F46 R55 E56 T57 R60 T62 G64 M65 A69 D70 R71 E73 P141 T142 D143 S144 R146 K148 S149 G150 R151 R152 R154 R155 L156
Binding residue
(residue number reindexed from 1)		H11 N17 D18 F20 R29 E30 T31 R34 T36 G38 M39 A43 D44 R45 E47 P114 T115 D116 S117 R119 K121 S122 G123 R124 R125 R127 R128 L129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xxu, PDBe:5xxu, PDBj:5xxu
PDBsum5xxu
PubMed28809395
UniProtA0A125YXW4

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