Structure of PDB 5t5h Chain O Binding Site BS01

Receptor Information
>5t5h Chain O (length=202) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRPEIIVVDLKDHVLGRAAAIVAKQLLLGKKITAVRCEQLTIAGTEIRNK
IKYLQFLRKRKLSNPKLGPFHHRSPSDIFLRTVRSMLPRYTKRGQKALRQ
LVAYEGIPTNVVRTGGRVVIPKAQRHYCYRSERPYTVLGNMCKHVGWKYS
DVVKKLETARVEKAARHHKKTEKLRAAWKSARKEALSKVSKNNLEVLKKF
GY
Ligand information
>5t5h Chain A (length=1278) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacuaag
cggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaaga
gggauccaacucguugccgaaucgguucuuauaggaacuugaguuguggc
aauggugcaggaauggugaaauucaaagcaaacccguugcuacaucaugu
gaguauugagccaaagaagguguuagcccauugagccaugaaccuaagag
aguagcacugcuugggagugcagugucaagcuggcagguaugugucugcc
aaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcg
aaaguuugaaaagcacuuuggaaagagagugacauagaccugaagucgug
acaauaauggaaguaccuccauuucgccaaaaccagccucuacugagcaa
gaacgaggucaugguuuuggcggaaauggggugcccccacccgucuugaa
acacggaccaaggagucaaacagacgcgcaagggagaagauaucaguacu
ucucucguacugaaagggagauuguggugugcacacuugcccaacaccga
ccggccccggguugaguuggagugugccuguuuggacccgaaagguggug
aacuaugccugaacaaggugaagcccggggaaacucggguggaggccugu
agcgaugcugacgugcaaaucgcucgcaugauuuggguaucggagcgaaa
gacucaucgaaccaccuaguagcugguucacaucgaaguuucccucagga
uagcuggugcuugaaaaaguauugugcgguaaagcuuuaaaugugcaacu
ugccaaagcaagguauuaaggcaccaagugggccuucuucgguaagcgga
gcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuau
gggcucacgaacaauggaugacgcucaagcccaauuagugcccauuauuc
cuuugguaagggcgagaaaguguagcccuuccgauguagauguggcgugg
agguaaggacgaagcugauggcgugagccucagauggaccagccucuagu
gcagaucuugguuggcguagcaaagaucuaacggaacguuggauacugga
gcggggaaggauuucgugccaacggcacucguacacgaguuguucggaua
cugagcacaacguuacaccguuuuuaggaaaaggggcaacagagaaccug
ggauuauauuccaaaaagaaauugcaug
.......................<<<<<......<......>.......>
>>>.>.........<<....>>...<<<<<......<<.....>>....>
>>>>....<<<..<<<<<<..<<<<<<<......>>>>>.>>....>>>>
>>......<<<.<<<<<......<<<<<<<.......>>>>.<.....>.
.....>>>.<<.......((.....>>)).....>>>>>...>>>.....
....<<<<<<<........>>>>>>>......<<<<<........>>>>>
..>>>....................................<<....>>.
...............<<<......>>>.......................
.......<<<..<<<<<<.<<<<<.<<<<<<<<<<<<<<...<<.>>...
.....>>>>..>>>>>>>>>>..>>>>>>>>>>>..>>>.<<<<......
..>>>><<<<<<...<<<<<<<<.<<<<<..<<<<..<<.<<<..>>>>>
..>>>>...<<....>>........<<<<<...<<..>>....>>>>><<
<<<<<<<.>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<<<<<.
....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>..
.<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.....
..>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>
(><<<<<<<<<.....<<...<<<<<<<...<<<.>>>...>>>>>>><<
<<<....>>>>>...>>..>>>>>>>.>>).<<<<.<<<<<.....>>>>
>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..
<<<<....<..........))).>....>>>>.>.....>>>...>>>>>
>><<<<.<<<<<.............>>>>>>>>>....>>>>>.....<<
<<<<..........<<<..<<<....>>>.>>>........>>>>>>...
......>>>>>>..............<<<<<<<...>>>>>>>.......
.............<<<<<....<<.....>>..>>>>>....<<......
....<<.<<<<<......>>>>...........>.>>..........<<<
<.........>>....>>.>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t5h Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		V33 L34 G35 R36 A39 I40 K43 L46 A62 R67 K78 R79 K80 L81 M105 P107 T110 K111 R112 K141 H145 Y146 C147 Y148 R149 R152
Binding residue
(residue number reindexed from 1)		V14 L15 G16 R17 A20 I21 K24 L27 A43 R48 K59 R60 K61 L62 M86 P88 T91 K92 R93 K122 H126 Y127 C128 Y129 R130 R133
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5t5h, PDBe:5t5h, PDBj:5t5h
PDBsum5t5h
PubMed27791004
UniProtV5DCT1

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