Structure of PDB 5li0 Chain O Binding Site BS01

Receptor Information

>5li0 Chain O (length=131) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325)

MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGF
EGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESG
VVKNEKSGIKILGNGSLDKKLTVKAHKFSAS

Ligand information

>5li0 Chain A (length=2914)

uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauaugugaauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguugua
ggacacucuauacggaguuacaaaggacgacauuagacgaaucaucugga
aagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucuc
uugaguggauccugaguacgacggagcacgugaaauuccgucggaaucug
ggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaacc
aguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauaga
accugaaaccgugugcuuacaaguagucagagcccguuaaugggugaugg
cgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaa
gcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuagu
auuuggucguagacccgaaaccaggugaucuacccuuggucagguugaag
uucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugag
cggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcu
gguucucuccgaaauagcuuuagggcuagccucaagugaugauuauugga
gguagagcacuguuuggacgaggggccccucggguaccgaauucagacaa
acuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaag
guccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaa
uauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguu
ggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucga
gugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugu
ggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagca
ugaucguaaggacauguggagcgcuuagaagugagaaugccggugugagu
cgcgaaagacgggugagaaucccguccaccgauugacuaagguuuccaga
ggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacag
gcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguu
uuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauug
cacgucuaagcaguaaggcugaguauuaggcaaauccgguacucguuaag
gcugagcugugauggggagaagacauugagucuucgagucguugauuuca
cacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaac
cgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucg
uuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucu
uuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguu
uaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcug
acgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaag
cuacgaaucgaagccccaguaaacggcggccguacuauaacgguccuaag
guagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaac
gauuugggcacugucucaacgagagacucggugaaaucauaguaccugug
aagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacu
guagccugauauugaaauucggcacagcuuguacaggauagguaggagcc
uuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuaccc
uagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagu
gucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggag
gcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaa
ggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaag
acggacuuagugauccggugguuccgcauggaagggccaucgcucaacgg
auaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacau
cgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcug
uagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagc
uggguucagaacgucgugagacaguucggucccuauccgucgugggcgua
ggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacaua
ccucugguguaccaguugucgugccaacggcauagcuggguagcuaugug
uggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagau
gagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaau
agguucgagguggaagcauggugacauguggagcugacgaauacuaaucg
aucgaagacuuaau

<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....
>>.......>>>>.>...[.....<<....>>..<<<<<......<<...
..>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<
<<<<<<<<.....<............<<<<<<<<.<<<...<<<<<....
..>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.....
>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<
<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...........
....<<....>>....]].........<<<<....>>>>...........
..}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>
>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...
<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>
>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<
<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>
>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.
>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.
....<<<...<<<<<<<....<<..<<<...>>>..>>....>>>>>>>.
.>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......
>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....
.<<<<<<...........<<..<<<<.<<<<........<<<<<.<<...
<<<.........>>>...>>......................>>>>>...
.>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>
>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<
<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><.....
<<<....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<
<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>
>>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......
....<<...<<<<....<<<<...<<...<....<.<<....[.[....>
>.>.<....<<<<...<<<.<<<<<<..<<.....>>.>>>>>>......
>>>...>>>>.....>..........................>....>>.
..>>>>.........>>>>..>>......>>>>>>>>>>>..>>.....<
<......>>.>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<
<<..<...............<<<<<.....<..>......>>>>><<<<<
<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.
........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.
<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>
>>>>...>>...>>>>>>>>..>>>>><<<<<<......>>>>>>.....
...<...........<<<<<.......>>>>>.....>....>>>>>..>
>.>>>>>>>.....>..>>>>>>>>.>>>>>>>....>.(...<<<<<..
.....)>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<
<<.<<<<<<<<<.<<<<.<<<<<<<<<<<...........<<<<<..<<<
......<<<<<<<<....>>>>>>>>...>>>............>>>>>.
.>>>>>>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>
>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>
>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.(
(>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>
>>.>>))))......<<<<<<<.((..>>>>..))>>>>>>>........
.....>>>>..))>>>>.......<<<<...<<<<<<...<<.......>
>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<.
.....>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>
>.>>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....
<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<
<...<<<<...<<<<<<<<<<<.].]>>>>>>..>>>>>...>>>>.>>>
>>...<<<....<<<<<...........>>>>>....>>>.>>>>.....
..>>>>>>>.<<<....>>>....<<<<<<<<.........>>>>....<
<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>
>>>....>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5li0 Structure of the 70S ribosome from human pathogen Staphylococcus aureus.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): L3 H4 L6 G11 R13 E15 R18 G20 R21 G22 K29 T30 G32 H35 G37 K39 R41 R47 P48 F50 Q54 P56 L57 F58 R59 R60 N68 E90 E98 S99
• Binding residue (residue number reindexed from 1): L3 H4 L6 G11 R13 E15 R18 G20 R21 G22 K29 T30 G32 H35 G37 K39 R41 R47 P48 F50 Q54 P56 L57 F58 R59 R60 N68 E90 E98 S99

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5li0, PDBe:5li0, PDBj:5li0
• PDBsum: 5li0
• PubMed: 27906650
• UniProt: P0A0F8|RL15_STAA8 Large ribosomal subunit protein uL15 (Gene Name=rplO)