Structure of PDB 5lcw Chain O Binding Site BS01

Receptor Information
>5lcw Chain O (length=685) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLS
KLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEV
HKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTPLSQKQA
EFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNL
RVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHC
RFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVLLE
HSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKH
SLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEQQNNTESFAV
ALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDR
AMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLL
VHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQY
LASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVA
KCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQA
RLYHTLGKTQERNRCAMLFRQLHQELPSVPLINHL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lcw Molecular basis of APC/C regulation by the spindle assembly checkpoint.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		A220 K224 Y255 Y277 L283 Y302 N306 R313 H342 W346 V349 Y375 L379 S383 Q386 F390 E416 I420 A427 E464 V468 C471 H472
Binding residue
(residue number reindexed from 1)		A158 K162 Y193 Y215 L221 Y240 N244 R251 H280 W284 V287 Y313 L317 S321 Q324 F328 E354 I358 A365 E396 V400 C403 H404
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019903 protein phosphatase binding
Biological Process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lcw, PDBe:5lcw, PDBj:5lcw
PDBsum5lcw
PubMed27509861
UniProtQ9UJX4|APC5_HUMAN Anaphase-promoting complex subunit 5 (Gene Name=ANAPC5)

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