Structure of PDB 5a31 Chain O Binding Site BS01

Receptor Information
>5a31 Chain O (length=685) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDWVTPYKIAVLVLLSEMSRTGEGAVSLVERRRLNQQLLPLLQGPDITVS
KLLKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEV
HKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQSDENKTPLSQKQA
EFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNL
RVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHC
RFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVLLE
HSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKH
SLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEQQNNTESFAV
ALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDR
AMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLL
VHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQY
LASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVA
KCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQA
RLYHTLGKTQERNRCAMLFRQLHQELPSVPLINHL
Ligand information
>5a31 Chain U (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB5a31 Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		Y715 R730 N731 F737 R738
Binding residue
(residue number reindexed from 1)		Y647 R662 N663 F669 R670
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019903 protein phosphatase binding
Biological Process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5a31, PDBe:5a31, PDBj:5a31
PDBsum5a31
PubMed26083744
UniProtQ9UJX4|APC5_HUMAN Anaphase-promoting complex subunit 5 (Gene Name=ANAPC5)

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