Structure of PDB 3jcs Chain O Binding Site BS01

Receptor Information
>3jcs Chain O (length=235) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNKAYFKRFQVKYRRRREGKTDYHARRQMVLQDKTKFGSPKYRLVVRITN
KDIIAQIVQAKIVGDEVVMAAYAHELPAFGIEHGLTNYAAAYATGLLLAR
RTLAKLGIADKFQGAKEADGSYSAVRFPFKAILDVGLARTTTGARVFGVL
KGAVDGGMAVPHRPNRFPGYNKEKSSLDAKVHRDRIFGKHVAEYLKQVKE
EASSAAKVLPESIEGMYKKAHAAIRADPSKSLPKK
Ligand information
>3jcs Chain 1 (length=1554) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacuguauuaag
cgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucug
ccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugag
cgaaaguuugaaaagcacuuuggaaagagagugaaauagaaccugaaguc
gugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccu
acugcauuauccugucggccggcgggcaacgaagugcaagaauuuugggu
cuuggugaaugcuccauggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggagauauccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccgggaacccagguggaggccuguagcgaugcugacgugcaaa
ucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuag
uagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaag
uauugugcgguaaagcaugauuagagguugguguuaauaucgaccuauuc
ucacuuuaaaugugcaaacaaaccugccuuagccugcaaggccggaaaga
aauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugcg
gaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucga
uacgugaaaaggguguugguggauaacaaauccaccggccccgaaaaugg
augacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggc
ggaaacuuggagaaaguguagcccuuccgauguagauguggccuggaggu
uaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcag
aucuugguuggcguagcaaagaucuaacggagacguuggauacuggagcg
gggaaggauuucgugccaacggcacucguacacgaguuguucggaaacug
agcacaacguuauaucguuuuguuaggaaagugaaggugugggccauaac
ugaaaaggggcaacagagaaccuggguuauauuccaaaaagaaauugcau
gugg
......................<<<<<......<<....>>.......>>
>>.>...<.....<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>
....<..<<.<<<<.<...<<<<..<<.<<<<<.......<.........
.<......<..........>.....>..........>............<
<.......>>.....>>>>>...>>....>>>>.>.>>>>.>>.>.....
......<<<<<<<........>>>>>>>......<<<<<........>>>
>>..>>>....>...............................<<....>
>................<<<<....>>>>.....................
.............<<<..<<<<<<.<<<<<.......<....<.<<....
..........<<<..........>>>.................>>.>...
.....<....>.......>......>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<.<<<<.<<<...>>
>>>.>>>>>...<<....>>.....<.....>.....<<<.......<..
..........>........>>>..<<<<<<<.<.......>.>>>>>.>>
....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<..>>>.>>>.....>>>...<<<..<<.<<........
>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...
...>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.
<.<<<<<<<...<<<..<<<....<<<<<<<<<<..>>>>>>>>>>....
>>>>>>....>>>>>>>.....<<.<<<...<<..>>..>>>.>>.....
.>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<
<..[...>>>>..<<<<<<<...<<<(((........<<<<<......<.
...]......<<...<<<<<<<<<.....>>>>>>>>>..>>........
..))).>....>>>>>..........>>>...>>>>>>><<<<.<<<<<.
.....................>>>>>>>>>....>>>>>....<<<<<<<
<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>......
..>>>>>>..............<<<<<<<....>>>>>>>..........
..........<<<<<....<<.....>>..>>>>>....<<.........
.<<.<<<<<......>>>>...............<<<<.......>>..>
>......>.>>..........<<<..........>....>>.>>......
....
Receptor-Ligand Complex Structure
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PDB3jcs 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		A11 K43 F44 S46 F148
Binding residue
(residue number reindexed from 1)		A4 K36 F37 S39 F129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3jcs, PDBe:3jcs, PDBj:3jcs
PDBsum3jcs
PubMed27373148
UniProtA0A3Q8IJC5

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