Structure of PDB 2zxw Chain O Binding Site BS01

Receptor Information

>2zxw Chain O (length=227) Species: 9913 (Bos taurus)

MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKL
THTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTM
GHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTI
RMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSSRPGLYYGQCSEIC
GSNHSFMPIVLELVPLKYFEKWSASML

Ligand information

• Ligand ID: CUA
• InChI: InChI=1S/2Cu
• InChIKey: ALKZAGKDWUSJED-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cu][Cu]
• Formula: Cu2
• Name: DINUCLEAR COPPER ION
• PDB chain: 2zxw Chain O Residue 228

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2zxw A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): H161 C196 E198 C200 H204 M207
• Binding residue (residue number reindexed from 1): H161 C196 E198 C200 H204 M207
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0022900 electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045277 respiratory chain complex IV

External links

• PDB: RCSB:2zxw, PDBe:2zxw, PDBj:2zxw
• PDBsum: 2zxw
• PubMed: 19164527
• UniProt: P68530|COX2_BOVIN Cytochrome c oxidase subunit 2 (Gene Name=MT-CO2)