Structure of PDB 2o93 Chain O Binding Site BS01

Receptor Information

>2o93 Chain O (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ASSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHP
VVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEK
IVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTR
VRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE
IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV

Ligand information

>2o93 Chain A (length=25) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agggactttccgctggggactttcc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2o93 Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element
Resolution	3.05 Å
Binding residue (original residue number in PDB)	Y424 T426 K520 R522 N523 R537 K538 R572 R665
Binding residue (residue number reindexed from 1)	Y33 T35 K129 R131 N132 R146 K147 R181 R274

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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External links

PDB	RCSB:2o93, PDBe:2o93, PDBj:2o93
PDBsum	2o93
PubMed	18462673
UniProt	Q13469\|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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