Structure of PDB 1fka Chain O Binding Site BS01

Receptor Information

>1fka Chain O (length=88) Species: 274 (Thermus thermophilus)

PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHH
SHRGLLMMVGQRRRLLRYLQREDPERYREIVEKLGLRG

Ligand information

>1fka Chain A (length=1479)

uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguacuccguggucagcggcggacgggu
gaguaacgcgugggugaccuacccggaagagggggacaacccggggaaac
ucgggcuaaucccccauguggacccgccccuugggguguguccaaagggc
uuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggua
auggcccaccaaggcgacgacggguagccggucugagaggauggccggcc
acaggggcacugagacacgggccccacuccuacgggaggcagcaguuagg
aaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaa
gaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacga
ggggacugacgguaccgggguaauagcgccggccaacuccgugccagcag
ccgcgguaauacggagggcgcgagcguuacccgcguaaagggcguguagg
cggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcg
ugggauacgcucaggcuagacggugggagagggugguggaauucccggag
uagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagc
caccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccg
gauuaacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggg
ucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacg
gccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcggug
gagcaugugguuuaauucgcgaagaaccuuaccaggccuugacaugcuag
ggaacccgggugaaagccuggggugcccgcgagggagcccuagcacaggu
gcugggccgucgucagcucgugccgugagguguuggguuaagucccgcaa
cgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaa
cgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagc
auggcccuuacggccugggcgacacacgugcuacaaugcccuacaaagcg
augccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucgg
auuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcg
gaucagccaugccgcggugaauacguucccgggccuuguacacaccgccc
gucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggc
aggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagc
uguaccggaaggugcggcuggaucaccuc

....<<<<<...((((>>>>>.<<<..<<<<<..<<<<<<...<.....<
...<..<<..<<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<
.......<<<<<<<...<<...<<<<<<<.<<<<<....<<<<<......
>>>>>.....>>>>>.....<<<.<<<<<....>>>>>.>>>....<<<<
...>>>>.>>>>>>>..>>.>>>>>>>.<<..<.<<<..<<<<<<<<.<.
...>>>>>>>>>>>>...>...>>..<<<<<<<......>>>...>>>>.
>>.<<<<<.<<.......>>>>>>>.<<<<....>>>>...>..>...>.
.....<<<....<<.<......>.>>..>>>....>>>>>>..<<<<...
...<<<<....>>>>.....>>>>....<<<<.<........<<<.....
>.>>..........>>>>>......<<<<<(((...<<<<<........)
)).........>>>>>>>>>>..>>>>>.>>><<.......<<<<...<<
<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>
>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<..
<.<<<......>>>......>>>>>>>>...........<<....>>.>>
>>>>>..>>>>.>>>>...>>>...>>>>....<<<<.<<..<<..<<<<
<......>>>>.>.>>>>>>>>..........<<<<<<<.<<<<<<<<<<
...>>>>>>>>>>...............>>>>>>>.>>..<........<
<<<....>>>>.....>...))))....<<<.<<<<<......<<<<<..
.<<<<<<<<<<....................<<<<<<.......<.<<<<
<<..<<<<<<<....>>>>>>>...<........>..>>>>>>.>..<<.
.<...<.<..<....<<<<<<<<<....>>>..<<<<......>>>>..>
>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>
>>>.....<<<<......>>>>........>>>>.....>....>>....
...>.>>.....>>>>>>...>>.>>>>>>>>.....<<<<.<<......
..<...<<<......>.>>..>.............>>>>>>.........
..<<<<<<<........>>>>>>>...........>>>>>....<<<<<<
<..........>>>>>>>.............>>>>>>>>..........<
<.<.<<<..<.<<.<<<<<<<<<<<<....<.<<<......<<<..>>>.
..>>>.>...>>>>>>>>>>>>..>>>..>>>..>.>>.........<<<
<<<<<<....>>>>>>>>>..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fka Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): P2 T22 G23 S24 K48 H50 H51 S52 R65 Y69
• Binding residue (residue number reindexed from 1): P1 T21 G22 S23 K47 H49 H50 S51 R64 Y68

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:1fka, PDBe:1fka, PDBj:1fka
• PDBsum: 1fka
• PubMed: 11007480
• UniProt: Q5SJ76|RS15_THET8 Small ribosomal subunit protein uS15 (Gene Name=rpsO)