Structure of PDB 8fl0 Chain NZ Binding Site BS01

Receptor Information
>8fl0 Chain NZ (length=49) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIPKGKPKSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKD
Ligand information
>8fl0 Chain L3 (length=1558) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguccgcccggaggauucaacccggcggcggccggccgugucggccgacc
ggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgac
cggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccg
aguguuacagcccccccggcagcagcacucgccgaaucccggggccgagg
gagucgccgcgcucuccccccggggggccgggccaccccucccacggcgc
gcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacg
gcggagcgcacggggucggcggcgcuaacacgugcgcgagucgggggcgc
cgccguggcgcggugggaucccgaggccgccgagggcgcaccaccggccc
gucucggagguggagcacgagcgcacguguuagcccuccgaaguuucccu
caggauagcuggcgcucuccgcaguuuuauccgggguaagaagcccggcu
cgcuggcguggagccgggcguggaaugcgagugccuaguggccacuuuug
guaagcagaacuggcgcgggaugaaccgaacgccggguuaaggcgcccga
ugccgacgcucaucagaccccagaaaagguguugguugauauagacagca
ggacgguggccauggaagucggaauccgcuaaggaguguguaacaacuca
ccugccgaaucaacuagcccugaaaaauggcgcuggagcgucgggcccau
acccggccgucgccggcaguacgcuacgccgcgacgaguaggagggccgc
ugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcag
gugcccuguugagcuugacucuagucgguggggaguuugggcgguacacc
uagguguccuaaggcgagcucagggaggacagaaaccucccguggagcag
aagggcaaaagcucgcuugaucuugauuuguacgaauacagaccgugaaa
gcggggccuaaguuaccacagggaggcuuguggcggccaagcgagcgacg
ucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaa
uucaccaagcguuggauuguucacccacuaauagggagcuggguuuagac
cgucgugagacagguuaguguuguugccaugguaauccugcucaguacga
gaggaaccgcagguucagacauuugguguaugugcuggggcgaagcuacc
aucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcg
gaacgauagcgccgcggagccucgguuggccucggauagccgguccccgg
gguccggugcggagugcccuucguccugggaaacggggcgcggccggaga
ggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccugg
cgcuaaaccauucguagacgaccugcuucugggucgggguuucguacgua
gcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaa
ggguuugu
...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<..>>>>>
>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<
<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>
>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...
........<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<.
.>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<.......>>>>>>>
.>>>>>>>>.....>>>.>>>>>.<<<<<<<<<<<<<..<<<...<<..>
>.....>>>..<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<<<
<<<<<.>>>>>>>.>>....>>>>>>>>>>>>><<<<<<......<<<..
..>>>..<<.<<<<<<<...<<<.<<<<<<<<.>>>>>>...<<<<<<<<
<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>.<<<<.<<<<<
.....>>>>>.>>>>.<<<......>>>...<<<<<<<...<<<(((...
....<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<
<<.<<<...<<.........>>...>>>.........<<......>>...
>>>>>...>>>>>>>>>>>>>.......))).>>...>>>>>..>>>...
>>>>>>><<<<<<.<<<..........>>>>>>>>>....>>>>>>...<
<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>
...<<<<<.<<<<<<..<<<<<.<<..>>..>>>>>..<<<<<<.<<<<<
..>>>>>.>>..<<<<<<<...<<<<<<.......>>>>>>.....<<..
....>>....>>>>>>>...<<<.<<<<<....>>>>.>>>><<<<....
>>>>.>>>>.>>>>..>>>>>>>........<<<<<<...<<..>>...>
>>>>>.................<<<<..<<<<<..<.<.<<<<<......
>>>>>...>.>.<<<.........>>>.....>>>>>>>>>......<<<
<<<<....>>>.>>>>...<<<<<<.<..<<<..<.<<<<<.........
........>>>>>.><<<<....<<<<....<<.<..>.>>...>>>>..
.>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>
.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>
>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<....
..>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>
>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<
<.<..<<<<<......>>>>>..>>>>>....>>....>>>.>>>>.>>.
.>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fl0 Principles of human pre-60 S biogenesis.
Resolution2.91 Å
Binding residue
(original residue number in PDB)		K237 G238 S242 R244 K247 R249 K251 K252 R253 F254 S255 Q256 R264 W267 Q268 K270 R274
Binding residue
(residue number reindexed from 1)		K4 G5 S9 R11 K14 R16 K18 K19 R20 F21 S22 Q23 R31 W34 Q35 K37 R41
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8fl0, PDBe:8fl0, PDBj:8fl0
PDBsum8fl0
PubMed37410842
UniProtQ9H6F5|CCD86_HUMAN Coiled-coil domain-containing protein 86 (Gene Name=CCDC86)

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