Structure of PDB 8fl4 Chain NU Binding Site BS01

Receptor Information
>8fl4 Chain NU (length=833) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QHDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQLKEDGTLPTNNRKL
NIKDLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVF
TDKDANVRLAAVQLLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQ
EDSLKVLDILLEQYPALITGRSSILLKNFVELISHQQLSQSWILSVNPNR
RLTSQQWRLKVLVRLSKFLQALADGSSRLNSIFINWKEHANDQQHIQVYE
NGGSQPNVSSQFRLRGLSSTENLKGFIEIIIPLLIECWVEAVPGIEREPL
QVMQQVLNIISLLWKLSKQQDETHKLESWLRKNYLIDFKHHFMSRFPYVL
NNIDHLLLNLTLSDIMVSLANASTLQKDCSWIEMIRKFVTETLEDGSRLN
SKQLNRLLGVSWRLMQIQPNREDTETLIKAVYTLYQQRGLILPVRTLLLK
FFSKIYQTYRSKVLSRWLAGLPLQLAHLGSRNPELSTQLIDIIHTAAARA
NKELLKSLQATALRIYDPQEGAVVVLPADSQQRLVQLVYFLPSLPADLLS
RLSRCCIMGRLSSSLAAMLIGILHMRSSFSGWKYSAKDWLMSDVDYFSFL
FSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYLTDLDQFLHHWDVTE
AVFHSLLVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVICKLLD
HTCVVSETLLPFLASCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILA
LLPRVLRLMLQSLRVNRVGPEELPVVGQLLRLLLQHAPLRTHMLTNAILV
QQIIKNITTLKSGSVQEQWLTDLHYCFNVYITG
Ligand information
>8fl4 Chain BD (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GLLWSQGQLHGLKTGLQLF
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fl4 Principles of human pre-60 S biogenesis.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		A630 S634 F663 Y668 D677 V678 F681 S682 F685 S686 P744 Q748 D751 I752 S755
Binding residue
(residue number reindexed from 1)		A546 S550 F579 Y584 D593 V594 F597 S598 F601 S602 P660 Q664 D667 I668 S671
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0071339 MLL1 complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8fl4, PDBe:8fl4, PDBj:8fl4
PDBsum8fl4
PubMed37410842
UniProtQ9NXF1|TEX10_HUMAN Testis-expressed protein 10 (Gene Name=TEX10)

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