Structure of PDB 8fkt Chain NO Binding Site BS01

Receptor Information

>8fkt Chain NO (length=305) Species: 9606 (Homo sapiens)

QLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHDELLKV
WKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMNR
EWTGIDRLRLDKFYMLMRMVLNESLKVLKMQGWEERQIEELLELLMTEIL
HPSSQAPNGVKSHFIEIFLEELTKVGAEELTADQNLKFIDPFCRIAARTK
DSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQDEEVASDSDGGPVLQF
DYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKA
CRRLL

Ligand information

>8fkt Chain L3 (length=2125)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggagga
uucaacccggcggcgccgggcgcauuuccaccgcggcggugcgccgcgac
cggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccg
aguguuacagcccccccggcagcagcacucgccgaaucccggggccgagg
ggucggcggcgacgucggcuacccacccgacccgucuugaaacacggacc
aaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccgug
gcgcaaggugggaucccgaggcccaguccgccgagggcgcaccaccggcc
gcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagc
ugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauc
cgguggguaagaagccggcguggaaugcgagugccuagugggccacuuuu
gguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgc
ccgaugccgacgcucaucagaccccagaaaagguguugguugauauagac
agcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucg
ggcccauacccggccgucgccggcagucgagaguggacggccgcggacgc
uacgccgcgacgaguaggagggccgcugcggugagccuugaagccuaggg
cgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagca
ggggcgauggccuccggcccucgcggagaugggcgccgcgaggcguccag
ugaaucucgcauguagguaagggaaguacugucccuaccuacuauccagc
gaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacc
cuguugagcuugacucuagucuggcacggugaagagacaugagaggugua
gaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuu
uuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagca
ggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaag
cgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcag
aauucaccaagcguuggauuguucacccacuaauagggaacgugagcugg
ggucgugagaccccuacugaugguuguugccaugguaauccugcucagua
cgagaggaaccgcagguucagacauuugguggugcuuggcugaggagcca
auggggcgaagcuaccaucugugggauuaugacugaacgccucuaaguca
gaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccuc
ggauagccgguccccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcac
guucguggggaaccuggcgcuaaaccauucguagacgaccugcuucuggg
ucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaa
gucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<.<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>.>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
...................<<<<<<<<..<<<......<<<<<<<<.<<<
.....<<<<<<<.>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<.
<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>
>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...
..>>.>>>>>>....>>>...>>>>>>>>..<<<<.<....>.>>>><<<
<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>
>>....<<<<<...<<<..<<.........>>..>>>....>>>>>.<<.
>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>
.>>..<<<<<<....<.<<<.>>>.><<.<<<<<<<...<<<.<<<<<<<
<...>>>>>>...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<<
<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<((
(.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<
.<<<<<.<<....<<.........>>....>>.........<<......>
>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>.
.>>>...>>>>>>><<<<<<.<<<.............<<..>>.......
...>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<
<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<..
.<<<<...........>>>>..<<<<<...<<<<<<<....>>>>>>>..
....>>.>>>..<<<<<<.<<<<<<<..>>.>>>>>>>>>>>.......>
....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<
<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<.....
.....<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>
>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>
>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<
..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<....
..>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>.
.<<<....>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<......
...........>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>
..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>
...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<...
.....<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>........
......>>>>..>>>>>>>>><<<<<.<.............>....<<.<
<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>
>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkt Principles of human pre-60 S biogenesis.
• Resolution: 2.81 Å
• Binding residue (original residue number in PDB): V23 N211 R215 Q319 R323
• Binding residue (residue number reindexed from 1): V18 N206 R210 Q271 R275

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing

Cellular Component

• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0005730 nucleolus
• GO:0030688 preribosome, small subunit precursor

External links

• PDB: RCSB:8fkt, PDBe:8fkt, PDBj:8fkt
• PDBsum: 8fkt
• PubMed: 37410842
• UniProt: P56182|RRP1_HUMAN Ribosomal RNA processing protein 1 homolog A (Gene Name=RRP1)