Structure of PDB 8fkq Chain NN Binding Site BS01

Receptor Information
>8fkq Chain NN (length=244) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRSRHQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRV
MEPLTASRLQVRKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRLP
GGPTLTFQVKKYSLVRDVVSSLRRHRMHEQQFAHPPLLVLNSFGPHGMHV
KLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDFRHYSIKVVP
VPDGDHNITEQQSAVRLTEIGPRMTLQLIKVQEGVGEGKVMFHS
Ligand information
>8fkq Chain L3 (length=1565) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggagg
agaagaaacuaaccaggauucccucaguaacggcgagugaacagggaaga
gcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgga
agacccgcuccccggcgccgcucguggggggcccaaguccuucugaucga
ggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgg
gcccgggucuucccggagucggguugcuugggaaugcagcccaaagcggg
ugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguac
cguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgug
aaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauuc
aacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
cccgaguguuacagcccccccggcagcagcacucgccgaaucccggggcc
gagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacgggg
ucggcggcgacgucggcuacccacccgacccgucuacacggaccaaggag
ucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaa
ggugggaucccgaggccgccgagggcgcaccaccggccgcacgagcgcac
guguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccg
aaguuucccucaggauagcuggcgcucucgcaguuuuauccgguggguaa
gaagccggcguggaaugcgagugccuagugggccacuuuuagaacuggcg
cugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucgg
cgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgc
cgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgg
gcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguu
ggaacaauguaggaccuacuauccagcgaaaccucagcacugaugauguu
guugccaugguaauccugcucaguacgagaggaaccgcagguucagacau
uugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugu
gggcccgcccaggcggaacgauagcgccgcggagccucgguuggccucgg
auagccgguccccgggguccggugcggagugcccuucguccugggaaacg
gggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacgu
ucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucggg
guuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcc
cucgacacgguuugu
........................<<<<<<............>>>>>.>.
........<<....>>..<<<<<<.....<<.....>>....>>>>>>..
<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<
<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>
>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>
>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<
<<<.>>>>>>..>>>..................................<
<....>>...............<<<<....>>>>................
................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<...
..<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<
<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<.
.>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>
>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>......
>>.>>>>>...>>>>>..>>>>>>>>>..<<<<....>>>><<<<<<...
.<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....
<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<.>>....>>>>>>
>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<...>>>>>>
...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<..>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<(((.......<<<<<..))
)......>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>
>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....
>>>>>>>>...>>>>>>>>>>..>.....>>>>>>.<.....<......<
<<<.....<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>....<<<
<<<.<..<<<....<<<<<.................>>>>>..<<<<...
.<<<<.....<..<<<<<<....>>>>>>....>....>>>>...>>>><
<<..>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<.....
...<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<
<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..........
....>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<
<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>
>>.>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fkq Principles of human pre-60 S biogenesis.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		G5 R6 S7 R8 H9 Q10 K11 R14 A17 N21 R36 C38 T39 R44 K66 K67 G78 P79 T91 T93 Y96 R119 S123 R127 H128 R129 H131 E132 K200 H298
Binding residue
(residue number reindexed from 1)		G2 R3 S4 R5 H6 Q7 K8 R11 A14 N18 R33 C35 T36 R41 K63 K64 G75 P76 T88 T90 Y93 R116 S120 R124 H125 R126 H128 E129 K197 H243
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006364 rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fkq, PDBe:8fkq, PDBj:8fkq
PDBsum8fkq
PubMed37410842
UniProtQ9NQ55|SSF1_HUMAN Suppressor of SWI4 1 homolog (Gene Name=PPAN)

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