Structure of PDB 8fkt Chain NK Binding Site BS01

Receptor Information

>8fkt Chain NK (length=67) Species: 9606 (Homo sapiens)

AKSLRSKWKRKMRAEKRKKNAPKEASRLKSILKLKRNKKTLLDQHGQYPI
WMNQRQRKRLKAKREKR

Ligand information

>8fkt Chain L3 (length=2125)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggagga
uucaacccggcggcgccgggcgcauuuccaccgcggcggugcgccgcgac
cggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccg
aguguuacagcccccccggcagcagcacucgccgaaucccggggccgagg
ggucggcggcgacgucggcuacccacccgacccgucuugaaacacggacc
aaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccgug
gcgcaaggugggaucccgaggcccaguccgccgagggcgcaccaccggcc
gcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagc
ugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauc
cgguggguaagaagccggcguggaaugcgagugccuagugggccacuuuu
gguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgc
ccgaugccgacgcucaucagaccccagaaaagguguugguugauauagac
agcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucg
ggcccauacccggccgucgccggcagucgagaguggacggccgcggacgc
uacgccgcgacgaguaggagggccgcugcggugagccuugaagccuaggg
cgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagca
ggggcgauggccuccggcccucgcggagaugggcgccgcgaggcguccag
ugaaucucgcauguagguaagggaaguacugucccuaccuacuauccagc
gaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacc
cuguugagcuugacucuagucuggcacggugaagagacaugagaggugua
gaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuu
uuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagca
ggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaag
cgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcag
aauucaccaagcguuggauuguucacccacuaauagggaacgugagcugg
ggucgugagaccccuacugaugguuguugccaugguaauccugcucagua
cgagaggaaccgcagguucagacauuugguggugcuuggcugaggagcca
auggggcgaagcuaccaucugugggauuaugacugaacgccucuaaguca
gaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccuc
ggauagccgguccccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcac
guucguggggaaccuggcgcuaaaccauucguagacgaccugcuucuggg
ucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaa
gucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<.<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>.>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
...................<<<<<<<<..<<<......<<<<<<<<.<<<
.....<<<<<<<.>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<.
<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>
>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...
..>>.>>>>>>....>>>...>>>>>>>>..<<<<.<....>.>>>><<<
<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>
>>....<<<<<...<<<..<<.........>>..>>>....>>>>>.<<.
>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>
.>>..<<<<<<....<.<<<.>>>.><<.<<<<<<<...<<<.<<<<<<<
<...>>>>>>...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<<
<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<((
(.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<
.<<<<<.<<....<<.........>>....>>.........<<......>
>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>.
.>>>...>>>>>>><<<<<<.<<<.............<<..>>.......
...>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<
<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<..
.<<<<...........>>>>..<<<<<...<<<<<<<....>>>>>>>..
....>>.>>>..<<<<<<.<<<<<<<..>>.>>>>>>>>>>>.......>
....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<
<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<.....
.....<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>
>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>
>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<
..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<....
..>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>.
.<<<....>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<......
...........>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>
..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>
...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<...
.....<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>........
......>>>>..>>>>>>>>><<<<<.<.............>....<<.<
<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>
>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkt Principles of human pre-60 S biogenesis.
• Resolution: 2.81 Å
• Binding residue (original residue number in PDB): A2 K3 S4 L5 R6 S7 K8 R11 K12 M13 R14 K17 R18 N82 K83 K84 H90 G91 Q92 N98 Q99 R100 R104 K106 R109
• Binding residue (residue number reindexed from 1): A1 K2 S3 L4 R5 S6 K7 R10 K11 M12 R13 K16 R17 N37 K38 K39 H45 G46 Q47 N53 Q54 R55 R59 K61 R64

Gene Ontology

Molecular Function

• GO:0001099 basal RNA polymerase II transcription machinery binding
• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0060999 positive regulation of dendritic spine development
• GO:0097484 dendrite extension

Cellular Component

• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0005730 nucleolus

External links

• PDB: RCSB:8fkt, PDBe:8fkt, PDBj:8fkt
• PDBsum: 8fkt
• PubMed: 37410842
• UniProt: Q9BRT6|LLPH_HUMAN Protein LLP homolog (Gene Name=LLPH)