Structure of PDB 7mq8 Chain NJ Binding Site BS01

Receptor Information
>7mq8 Chain NJ (length=827) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHRKKVDNRIRILIENGVAERQRSLFVVVGDRGKDQVVILHHMLSKATVK
ARPSVLWCYKKELGFSSHRKKRMRQLQQDDPFELFIAATNIRYCYYNETH
KILGNTFGMCVLQDFEALTPNLLARTVETVEGGGLVVILLRTMNSLKQLY
TVTMDVHSRYRTEDVVGRFNERFILSLASCKKCLVIDDQLNILPISSHVA
TMEALPPLGPSDLELRELKESLQDTQPVGVLVDCCKTLDQAKAVLKFIEG
ISEKTLRSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLH
TLFEFVFKGFDALQYQEHLDYEIIQSLNPEFNKAVIRVNVFREHRQTIQY
IHPADAVKLGQAELVVIDEAAAIPLPLVKSLLGPYLVFMASTINLSLKLI
QQLRQQARTLYEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCP
LPEACELYYVNRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSD
APAHHLFCLLPPVPPTQNALPEVLAVIQVCLEGEIGDLIPWTVSEQFQDP
DFGGLSGGRVVRIAVHPDYQGMGYGSRALQLLQMYYEGRFPCEIHTVSSE
AVSLLEEVITPRKDLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRA
GFVPVYLRQTPNDLTGEHSCIMLKTGWLAAFWKDFRRRFLALLSYQFSTF
SPSLALNIIQNRNMGKPAQPALSREELEALFLPYDLKRLEMYSRNMVDYH
LIMDMIPAISRIYFLNQLGDLALSAAQSALLLGIGLQHKSVDQLEKEIEL
PSGQLMGLFNRIIRKVVKLFNEVQEKA
Ligand information
>7mq8 Chain L1 (length=1301) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accugguugauccugccaguagcauaugcuugucucaaaaagccaugucu
aaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucagu
uaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucu
agagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauu
uaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggc
uagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauu
cgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccaugg
ugaccacgggugagggaaucaggguucgauuccggagagggagccugaga
aacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgac
ccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccu
guaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagg
gcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaag
cucguaguuggaucauuaagagggacggccgggggcauucguauugcgcc
gcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagca
uuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaug
guugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagcc
ugcggcacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccguggguuggugcauggccguucguugguggagcgauuuggu
uaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccguccgggcg
cgcgcuacacugacuggcucagcguguaaccccauucguaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcgga
a
....................<<.<<<<<<...<.<<.....<<<..<<..
..<<....<<..........>>...>>.>>........<.......<<<.
<....<<....<<<................<<.....<<.<<.......>
>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<
<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>....
..>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>..
.>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>
>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<.....
...>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<...
..>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>
>>.>>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>............>>>>>>..>>>>>>.>>....<
.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<..<<<<<<<
<...<<<......>>>......>>>>>>>>..>>.......<<....>>.
..>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>..>>>..............
.....................<<<<<<<<<<<<..<<..<<<<<..<<<.
<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>>.<<.
.....>>....>>.>>>....<<<...<...<..>..>.....<<<<<..
...>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>
>>.>>>.....<<.<<<..............>>>.>>......>>>>>..
...<<<<<<<.........>>>>>>>......>>...>>>>>>>......
....>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<
<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>.
.>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>
>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mq8 Nucleolar maturation of the human small subunit processome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Y59 K71 R74 Y104
Binding residue
(residue number reindexed from 1)		Y59 K71 R74 Y93
Enzymatic activity
Enzyme Commision number 2.3.1.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0051392 tRNA N-acetyltransferase activity
GO:0070182 DNA polymerase binding
GO:0106162 mRNA N-acetyltransferase activity
GO:1990883 rRNA cytidine N-acetyltransferase activity
Biological Process
GO:0000154 rRNA modification
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0006473 protein acetylation
GO:0008033 tRNA processing
GO:0010824 regulation of centrosome duplication
GO:0016072 rRNA metabolic process
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0042274 ribosomal small subunit biogenesis
GO:0045727 positive regulation of translation
GO:0051391 tRNA acetylation
GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030496 midbody
GO:0032040 small-subunit processome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mq8, PDBe:7mq8, PDBj:7mq8
PDBsum7mq8
PubMed34516797
UniProtQ9H0A0|NAT10_HUMAN RNA cytidine acetyltransferase (Gene Name=NAT10)

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