Structure of PDB 7mq8 Chain NI Binding Site BS01

Receptor Information

>7mq8 Chain NI (length=234) Species: 9606 (Homo sapiens)

PSPLGYAAIPIKFSEKQQASHYLYVRAHGVRQGTKSTWPQKRTLFVLNVP
PYCTEESLSRLLSTCGLVQSVELQEKPDLAESPKESRSKFFHPKPVPGFQ
VAYVVFQKPSGVSAALALKGPLLVSTESHPVKSGIHKWISDYADSVPDPE
ALRVEVDTFMEAYDQKIAEEEAKAKEEEGVPDEEGWVKVTRRGRRPVLPR
TEAASLRVLERERRKRSRKELLNFYAWQHRESKM

Ligand information

>7mq8 Chain L1 (length=1301)

accugguugauccugccaguagcauaugcuugucucaaaaagccaugucu
aaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucagu
uaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucu
agagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauu
uaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggc
uagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauu
cgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccaugg
ugaccacgggugagggaaucaggguucgauuccggagagggagccugaga
aacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgac
ccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccu
guaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagg
gcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaag
cucguaguuggaucauuaagagggacggccgggggcauucguauugcgcc
gcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagca
uuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaug
guugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagcc
ugcggcacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccguggguuggugcauggccguucguugguggagcgauuuggu
uaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccguccgggcg
cgcgcuacacugacuggcucagcguguaaccccauucguaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcgga
a

....................<<.<<<<<<...<.<<.....<<<..<<..
..<<....<<..........>>...>>.>>........<.......<<<.
<....<<....<<<................<<.....<<.<<.......>
>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<
<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>....
..>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>..
.>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>
>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<.....
...>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<...
..>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>
>>.>>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>............>>>>>>..>>>>>>.>>....<
.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<..<<<<<<<
<...<<<......>>>......>>>>>>>>..>>.......<<....>>.
..>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>..>>>..............
.....................<<<<<<<<<<<<..<<..<<<<<..<<<.
<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>>.<<.
.....>>....>>.>>>....<<<...<...<..>..>.....<<<<<..
...>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>
>>.>>>.....<<.<<<..............>>>.>>......>>>>>..
...<<<<<<<.........>>>>>>>......>>...>>>>>>>......
....>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<
<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>.
.>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>
>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mq8 Nucleolar maturation of the human small subunit processome.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): R211 R212 R224 R228 K232 R235
• Binding residue (residue number reindexed from 1): R194 R195 R207 R211 K215 R218

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0001825 blastocyst formation
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis
• GO:0061523 cilium disassembly
• GO:1902570 protein localization to nucleolus

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005813 centrosome
• GO:0005856 cytoskeleton
• GO:0005929 cilium
• GO:0032040 small-subunit processome
• GO:0032545 CURI complex
• GO:0034456 UTP-C complex
• GO:0042995 cell projection

External links

• PDB: RCSB:7mq8, PDBe:7mq8, PDBj:7mq8
• PDBsum: 7mq8
• PubMed: 34516797
• UniProt: Q9Y3A4|RRP7A_HUMAN Ribosomal RNA-processing protein 7 homolog A (Gene Name=RRP7A)