Structure of PDB 7mq8 Chain NH Binding Site BS01

Receptor Information

>7mq8 Chain NH (length=1066) Species: 9606 (Homo sapiens)

EILFHSSLLRLQVEELLKEVRLSEKKKDRIDAFLREVNQRVVRVPSVPET
ELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPD
INVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVCF
SYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVR
SAWYRGQSPAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLK
DGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVL
RSVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNL
CADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPMIRAFDHVLH
LRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLL
AHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPE
AAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLAL
HADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWG
LEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLD
KPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGL
QCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASL
RLERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADES
LDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNEL
TVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVV
LAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQA
VDSPAASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYD
QHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILED
FAVLGEGLVQTVEARS

Ligand information

>7mq8 Chain L1 (length=1301)

accugguugauccugccaguagcauaugcuugucucaaaaagccaugucu
aaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucagu
uaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucu
agagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauu
uaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggc
uagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauu
cgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccaugg
ugaccacgggugagggaaucaggguucgauuccggagagggagccugaga
aacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgac
ccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccu
guaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagg
gcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaag
cucguaguuggaucauuaagagggacggccgggggcauucguauugcgcc
gcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagca
uuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaug
guugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagcc
ugcggcacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccguggguuggugcauggccguucguugguggagcgauuuggu
uaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccguccgggcg
cgcgcuacacugacuggcucagcguguaaccccauucguaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcgga
a

....................<<.<<<<<<...<.<<.....<<<..<<..
..<<....<<..........>>...>>.>>........<.......<<<.
<....<<....<<<................<<.....<<.<<.......>
>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<
<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>....
..>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>..
.>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>
>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<.....
...>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<...
..>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>
>>.>>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>............>>>>>>..>>>>>>.>>....<
.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<..<<<<<<<
<...<<<......>>>......>>>>>>>>..>>.......<<....>>.
..>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>..>>>..............
.....................<<<<<<<<<<<<..<<..<<<<<..<<<.
<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>>.<<.
.....>>....>>.>>>....<<<...<...<..>..>.....<<<<<..
...>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>
>>.>>>.....<<.<<<..............>>>.>>......>>>>>..
...<<<<<<<.........>>>>>>>......>>...>>>>>>>......
....>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<
<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>.
.>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>
>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mq8 Nucleolar maturation of the human small subunit processome.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): K149 R186 L189 Q190 K192 C265 R266 K271 R275 R801 Q804
• Binding residue (residue number reindexed from 1): K74 R111 L114 Q115 K117 C190 R191 K196 R200 R726 Q729

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006409 tRNA export from nucleus
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0000794 condensed nuclear chromosome
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0032040 small-subunit processome
• GO:0032545 CURI complex
• GO:0034456 UTP-C complex

External links

• PDB: RCSB:7mq8, PDBe:7mq8, PDBj:7mq8
• PDBsum: 7mq8
• PubMed: 34516797
• UniProt: Q9H6R4|NOL6_HUMAN Nucleolar protein 6 (Gene Name=NOL6)