Structure of PDB 8fkq Chain NG Binding Site BS01

Receptor Information

>8fkq Chain NG (length=89) Species: 9606 (Homo sapiens)

QERLEKIKQRDKRLEWEMMCRVKPDVVQDKETERNLQRIATRGVVQLFNA
VQKHQKNVDEKVKEAGSSMRKRAKLISTVSKKDFISVLR

Ligand information

>8fkq Chain L3 (length=1565)

gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggagg
agaagaaacuaaccaggauucccucaguaacggcgagugaacagggaaga
gcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgga
agacccgcuccccggcgccgcucguggggggcccaaguccuucugaucga
ggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgg
gcccgggucuucccggagucggguugcuugggaaugcagcccaaagcggg
ugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguac
cguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgug
aaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauuc
aacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
cccgaguguuacagcccccccggcagcagcacucgccgaaucccggggcc
gagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacgggg
ucggcggcgacgucggcuacccacccgacccgucuacacggaccaaggag
ucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaa
ggugggaucccgaggccgccgagggcgcaccaccggccgcacgagcgcac
guguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccg
aaguuucccucaggauagcuggcgcucucgcaguuuuauccgguggguaa
gaagccggcguggaaugcgagugccuagugggccacuuuuagaacuggcg
cugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucgg
cgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgc
cgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgg
gcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguu
ggaacaauguaggaccuacuauccagcgaaaccucagcacugaugauguu
guugccaugguaauccugcucaguacgagaggaaccgcagguucagacau
uugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugu
gggcccgcccaggcggaacgauagcgccgcggagccucgguuggccucgg
auagccgguccccgggguccggugcggagugcccuucguccugggaaacg
gggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacgu
ucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucggg
guuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcc
cucgacacgguuugu

........................<<<<<<............>>>>>.>.
........<<....>>..<<<<<<.....<<.....>>....>>>>>>..
<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<
<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>
>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>
>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<
<<<.>>>>>>..>>>..................................<
<....>>...............<<<<....>>>>................
................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<...
..<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<
<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<.
.>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>
>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>......
>>.>>>>>...>>>>>..>>>>>>>>>..<<<<....>>>><<<<<<...
.<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....
<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<.>>....>>>>>>
>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<...>>>>>>
...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<..>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<(((.......<<<<<..))
)......>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>
>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....
>>>>>>>>...>>>>>>>>>>..>.....>>>>>>.<.....<......<
<<<.....<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>....<<<
<<<.<..<<<....<<<<<.................>>>>>..<<<<...
.<<<<.....<..<<<<<<....>>>>>>....>....>>>>...>>>><
<<..>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<.....
...<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<
<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..........
....>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<
<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>
>>.>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkq Principles of human pre-60 S biogenesis.
• Resolution: 2.76 Å
• Binding residue (original residue number in PDB): Q135 R139
• Binding residue (residue number reindexed from 1): Q9 R13

Gene Ontology

Biological Process

• GO:0000460 maturation of 5.8S rRNA
• GO:0000470 maturation of LSU-rRNA
• GO:0006364 rRNA processing

Cellular Component

• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:8fkq, PDBe:8fkq, PDBj:8fkq
• PDBsum: 8fkq
• PubMed: 37410842
• UniProt: Q9Y3B9|RRP15_HUMAN RRP15-like protein (Gene Name=RRP15)