Structure of PDB 8fkp Chain NG Binding Site BS01

Receptor Information

>8fkp Chain NG (length=89) Species: 9606 (Homo sapiens)

QERLEKIKQRDKRLEWEMMCRVKPDVVQDKETERNLQRIATRGVVQLFNA
VQKHQKNVDEKVKEAGSSMRKRAKLISTVSKKDFISVLR

Ligand information

>8fkp Chain L3 (length=1507)

gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggagg
agaagaaacuaaccaggauucccucaguaacggcgagugaacagggaaga
gcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgga
agacccgcuccccggcgccgcucguggggggcccaaguccuucugaucga
ggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgg
gcccgggucuucccggagucggguugcuugggaaugcagcccaaagcggg
ugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguac
cguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgug
aaaccguuaagaggacgggugggguccgcgcaguccgcccggaggauuca
acccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgc
gaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggc
ccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccg
gcggcgacgucggcuacccacccgacccgucacggaccaaggagucuaac
acgugcgcgagucgggggcucgcacgaaagccgccguggcgcaagguggg
aucccgaggccaguccgccgagggcgcaccaccggccgcacgagcgcacg
uguuaggacccgaagcugguucccuccgaaguuucccucaggauagcugg
cgcucucgcaguuuuauccgggguaagaagccggcguggaaugcgagugc
cuagugggccacuuuuagaacuggcgcugcgggaugaaccgaacgccggg
uuaaggcgcccgaugccgacgcucggcgcuggagcgucgggcccauaccc
ggccgucgccggcagucgagaguggacggcgcggacgcuacgccgcgacg
aguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggg
uggagccgccgcaggugcagaucuuggugguaguagcaauguuggaacaa
uguaggaccuacuauccagcgaaaccucagcacugaugaguuguugccau
gguaauccugcucaguacgagaggaaccgcagguucagacauuuggugua
ugugcuuggcugaggagccaauggggcgaagcuaccaucugugggcccgc
ccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgg
uccccgggguccggugcggagugcccuucguccugggaaacggggcgcgg
ccggagaggcggccgcccccucgcccgucacgcaccgcacguucgugggg
aaccuggcgcuaaaccauucguagacgaccugcugggucgggguuucgua
cguagcagagcagcucccucgcugcgaucuauugaaagagcccucgacac
gguuugu

........................<<<<<<............>>>>>.>.
........<<....>>..<<<<<<.....<<.....>>....>>>>>>..
<<<..<.<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>.>..<<<
<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>
>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>
>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<
<<<.>>>>>>..>>>..................................<
<....>>...............<<<<....>>>>................
...............<<<<<<<<..<<<......<<<<<<<<.<<<....
.<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<
...<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..
>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>
>>>>>>....>>>...>>>>>>>>..<<<...>>><<<<<<....<<<<<
<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<.
..<<<..<<........>>..>>>....>>>>>.<<.>>....>>>>>>>
>>>>>>..<<.<...>.>>..<<<<<<....<.<<<....>>>.><<.<<
<<<<<..<<<.<<<<<<<<.>>>>>>...<<..>>....>>>>>>>>>>>
>..>>..<<<<.<<<..>>>.>>>>....<<<......>>>...<<<<<<
<...<<<(((.......<<<<<..)))......>>>>>..>>>...>>>>
>>><<<<<<.<<<..............<.>...........>>>>>>>>>
....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>
>...>>>>>>>>>>..>.....>>>>>>.<.....<......<<<<....
.<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>...<<<<<<.<..<
<<....<<<<<.................>>>>>..<<<<....<<<<...
<.<..<<<<<<....>>>>>>....>...>>>>>...>>>><<<..>>>.
>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<
.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<
<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>
..>>>>>>>>.<<<<<.<.............>..<.<<<<<<<<<<....
.<<<<....<<<<<......>>>>>...>>>>....>>.>>>>>.>>>.>
>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkp Principles of human pre-60S biogenesis
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): Q135 R139 W142
• Binding residue (residue number reindexed from 1): Q9 R13 W16

Gene Ontology

Biological Process

• GO:0000460 maturation of 5.8S rRNA
• GO:0000470 maturation of LSU-rRNA
• GO:0006364 rRNA processing

Cellular Component

• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:8fkp, PDBe:8fkp, PDBj:8fkp
• PDBsum: 8fkp
• PubMed: 37410842
• UniProt: Q9Y3B9|RRP15_HUMAN RRP15-like protein (Gene Name=RRP15)