Structure of PDB 7mq8 Chain NG Binding Site BS01

Receptor Information

>7mq8 Chain NG (length=116) Species: 9606 (Homo sapiens)

ENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAA
MLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGM
KIGRIEDVTPIPSDST

Ligand information

>7mq8 Chain L1 (length=1301)

accugguugauccugccaguagcauaugcuugucucaaaaagccaugucu
aaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucagu
uaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucu
agagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauu
uaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggc
uagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauu
cgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccaugg
ugaccacgggugagggaaucaggguucgauuccggagagggagccugaga
aacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgac
ccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccu
guaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagg
gcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaag
cucguaguuggaucauuaagagggacggccgggggcauucguauugcgcc
gcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagca
uuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaug
guugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagcc
ugcggcacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccguggguuggugcauggccguucguugguggagcgauuuggu
uaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccguccgggcg
cgcgcuacacugacuggcucagcguguaaccccauucguaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcgga
a

....................<<.<<<<<<...<.<<.....<<<..<<..
..<<....<<..........>>...>>.>>........<.......<<<.
<....<<....<<<................<<.....<<.<<.......>
>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<
<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>....
..>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>..
.>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>
>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<.....
...>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<...
..>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>
>>.>>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>............>>>>>>..>>>>>>.>>....<
.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<..<<<<<<<
<...<<<......>>>......>>>>>>>>..>>.......<<....>>.
..>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>..>>>..............
.....................<<<<<<<<<<<<..<<..<<<<<..<<<.
<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>>.<<.
.....>>....>>.>>>....<<<...<...<..>..>.....<<<<<..
...>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>
>>.>>>.....<<.<<<..............>>>.>>......>>>>>..
...<<<<<<<.........>>>>>>>......>>...>>>>>>>......
....>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<
<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>.
.>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>
>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mq8 Nucleolar maturation of the human small subunit processome.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): N38 D39 F41 H43 G49 T52 R55 T57 G59 D65 R66 S137 D138
• Binding residue (residue number reindexed from 1): N14 D15 F17 H19 G25 T28 R31 T33 G35 D41 R42 S113 D114

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0045182 translation regulator activity
• GO:0048027 mRNA 5'-UTR binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0006417 regulation of translation
• GO:0030218 erythrocyte differentiation
• GO:0030490 maturation of SSU-rRNA
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0014069 postsynaptic density
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7mq8, PDBe:7mq8, PDBj:7mq8
• PDBsum: 7mq8
• PubMed: 34516797
• UniProt: P62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)