Structure of PDB 7suk Chain NF Binding Site BS01

Receptor Information

>7suk Chain NF (length=124) Species: 4932 (Saccharomyces cerevisiae)

LSSESVIEQIVKYARKGLTPSQIGVLLRDAHGVTQARVITGNKIMRILKS
NGLAPEIPEDLYYLIKKAVSVRKHLERNRKDKDAKFRLILIESRIHRLAR
YYRTVAVLPPNWKYESATASALVN

Ligand information

>7suk Chain 8 (length=1192)

agauaguuaucugguugauccugccaguagucauaugcuugucucagcca
ugcagcucauuaaaucaguuaucguuuauuugauagucaugguauaacug
ugguaauucuagagcuaaaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaauaacuuuucgaaucgcauggc
cuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaug
guaggauaguggccuaccaugguuucaacggguaacggggaauaaggguu
cgauuccggagagggagccugagaaacggcuaccacauccaaggaagggc
aggcuuacccaauccuaauucagggagguagugacaauaaauaacgauac
agggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuua
acgaggaacaauuggagggcaagucuggugccagcagccgcgguaauucc
agcuccaauagcguauauuagcucguaguugaacuauuaauagggacggu
cgggggcaucaguauucaauugucagaggugaaauucuuggauuuauuga
agacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaaga
acgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaagac
uagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaa
aucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcucaacac
ggggaaacucaccagguccagacacaauauuugugggugguggugcaugu
gaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaac
cuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccu
aguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguac
acaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggau
cugcuuagagaagggggcaacuccucucagagcggagauuuggacaaacu
uggucauuuagaggaacuaauuccguaggugaaccugcggaa

................................<<<<<<.....<..<<<.
<<<..<<<.......<<<..<<..<.....<<<..............<<.
.<<.....>>..>>............<<....>>...........<<<<.
..........<....>............>>>>...........<<...<<
.....>>..>>......>>>....>>>..>>>...<....<<<....<<<
<<<<<.......>>>>>>>>>>>......>......<<<...........
....>>>.>>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>
>>>>..<<<....<<<.....>>>..>>>.......>.......<<<<<<
<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..
>>........<<<<<<<.......<<<....>>>................
..>>>>>>>.>>>>>>......<<..................<..<<<.<
<...<<<.......<<<<.......<<<......>>>..........>>>
>..........<<<....>>>...>>>..>>.>>>...>.........>>
..........<<........<...............>.....>>......
.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>........
........................................<<........
.>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.........
...........<<<<<......<<<<.....>>>>......<<<......
...>>>.....>>>>>>>>>.>>>.....<<<<<<<............<<
<..<<<<....>>>>..>>>.....>>>>>>>............>>>>>>
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>.....
.......>>>>>..<<<<.<<....<<<<<<<<.<<<....<<......<
<<<<<<.<<<<.<.<......>>.>>>>.>>>>>>>.....>>....>>>
.>>>>>>>>...>>.>>>>..<<<<<<<<....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7suk Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome.
• Resolution: 3.99 Å
• Binding residue (original residue number in PDB): P47 S48 G51 V52 Q62 A63 I71 M72 R73 E86 D87 Y90 L91 S97 V98 K109 A111 F113 I116 E119 S120 R121 I122 H123 R124 L125 A126 R127 Y129 V134
• Binding residue (residue number reindexed from 1): P20 S21 G24 V25 Q35 A36 I44 M45 R46 E59 D60 Y63 L64 S70 V71 K82 A84 F86 I89 E92 S93 R94 I95 H96 R97 L98 A99 R100 Y102 V107

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:7suk, PDBe:7suk, PDBj:7suk
• PDBsum: 7suk
• PubMed: 35650250
• UniProt: P05756|RS13_YEAST Small ribosomal subunit protein uS15 (Gene Name=RPS13)