Structure of PDB 8ipa Chain NA Binding Site BS01

Receptor Information
>8ipa Chain NA (length=116) Species: 4565 (Triticum aestivum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTSVTFHRPKTLSKARDPKYPRISTPGRNKLDQYQILKYPLTTESAMKKI
EDNNTLVFIVDLKADKKKIKAAVKKMYDIQAKKVNTLIRPDGKKKAYVKL
TPDYDALDVANKIGII
Ligand information
>8ipa Chain RB (length=3147) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaaua
agcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaac
cgggagcagcccagcuugagaaucgggcggcugugccguccgaauuguag
ucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaagg
ggcgccugggagggugagagccccguccggcccggacccugucgccccac
gaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggc
gguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaa
guaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagug
cuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggc
gcucggggcguggacuguugucggccgcgccggcggccaaagcccggggg
cuccgcgcccccggcagccgucgucggcacggccgguacccgcgcgccga
aaggcgugccccucggggcacugcgcugcaacgcccugcgggcucuccau
ccgacccgucuugaaacacggaccaaggagucugacaugcgugcgagucg
acggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggccc
ucacgggccgcaccgcuggccgacccugaucuucugugaaggguucgagu
uggagcacgccugucgggacccgaaagauggugaacuaugccugagcggg
gcgaagccagaggaaacucugguggaggcucgaagcgauacugacgugca
aaucguucgucugacuuggguauaggggcgaaagacuaaucgaaccaucu
aguagcugguucccuccgaaguuucccucaggauagcuggagcccauuac
gaguucuaucagguaaagccaaugauuagaggcauuggggacgcaacguc
cucgaccuauucucaaacuuuaaauagguaggauggcgcggcugcuucgg
ugagccgugccauggaaucgggugcuccaagugggccauuuuugguaagc
agaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacug
cgcgcuaaccuagaacccacaaaggguguuggucgauuaagacagcagga
cgguggucauggaagucgaaauccgcuaaggaguguguaacaacucaccu
gccgaaucaacuagccccgaaaauggauggcgcugaagcgcgcgacccac
acccggccaucugggcgagugccaugccccgaugaguaggagggcgcggc
ggccgaugcaaaacccggggcgcgagcccgggcggagcggccgucggugc
agaucuuggugguaguagcaaauauucaaaugagaacuuugaaggccgaa
gaggagaaagguuccaugugaacggcacuugcacauggguaagccgaucc
uaagggaagggguaaccccggcagauagcgcgaucacgcgcauccccgaa
agggaaucggguuaagauuucccgagccgggauguggcgguugacggcga
cguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuu
ucugcuuaacggccugccaacccuggaaacgguucagccggagguagggu
ccaguggccggaagagcacacgucgcgcgguguccggugcgcccccggcg
gcccaugaaaauccggaggaccgaguaccguucacgcccggucguacuca
uaaccgcaucaggucuccaaggugaacagccucuggccaauggaacaaug
uaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauug
gcucugaggacugacagucgacucagaacugguacggacaaggggaaucc
gacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacg
caaugugauuucugcccagugcucugaaugucaaagugaagaaauucaac
caagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaa
augccucgucaucuaauuagugacgcgcaugaaugaauuaacgagauucc
cacugucccugucuacuauccagcgaaaccacagccaagggaacgggcuu
ggcggaaucagcggggaaagaagacccuguugagcuugacucuaguccga
cuuugugaaaugaauuuuacuuauuccgugggucggaagcggggcaugcc
ccuccuuuuggcuccaaggcccggucuuaccgggccgauccgggcggaag
acauugucagguggggaguuuggcuggggcggccaaucuguuaaaagaua
acgcagguguccuaagaugagcucaacgagaacagaaaucucguguggaa
caaaaggguaaaagcucguuugauucugauuuccaguacgaauacgaacc
gugaaagcguggccuaucgauccuuuagaucuucggaguuugaagcuaga
ggugucagaaaaguuaccacagggauuacuggcuuguggcagccaagcgu
ucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauu
gcgaagcagaauucaccaaguguuggauuguucacccaccaauagggaac
gugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugau
gacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauuc
acacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuacc
gugugccggauuaugacugaacgccucuaagucagaauccaagcuagcau
gcgacgccugcgcccgccgcccgccccgacccacguuaggggcgcuugcg
cccccaagggcccgugccauuggcuaagccgguccggccgaagugccgcg
gucggccgccucgaagcucccuucccaacgggcggugggcugaauccuuu
gcagacgacuuaaauacgcgacggggcauuguaaguggcagaguggccuu
gcugccacgauccacugagauccaguccccgggucgcacggauucgu
..........................<<<<<.....<......>......
>>>>>...........<<....>>..<<<<<.......<.....>.....
.>>>>>..[[[....<......<<<<<<<<<...>>>>>>>>>......>
......<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>
>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....
>>>>>>>>.>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<......<<<<<<<<<.
..>>>>>>>>>.<..<<<<<<<<<<<<.<<<<<<<<<......<<<<<<<
.......>>>>>>>.....>>>>>>>>>.>>>>>>>.....<<<<<<<..
..>>>.<<<<<<..>>>>>>..>>>>..>>>>>..>....>>>.>>>>>>
>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<..
..<<<<<....>>>>>.....>>...<<....>>....<<<<<..<<<<<
....>>>>>...>>>>><<<<<<<<.....<....>.....>>.>>>.>>
>...>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<......
..>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>.
..>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<
<<.<<<<<<<.....<<<....<<<..<.<<<.....<<<<.......>>
>>...>>>.>..>>>..>.>>.....>>>>>...<<<<<<<<<.<.....
.>>>>>>>>>>....>>>>>>>.>>>>>>.>>..<<<<.<<<<<.....>
>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<
<<<<<......<<..........<<<.<<<<<<.<<<.......<<<...
<<.....<.........>.....>>........................>
>>...>>>.>>>>>>>>>..........))).>>...>>>>>>.>>>...
>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>>..<<<<
<<<<<........<<<.<<<<....>>>>>>>.....>>>>>>>>>....
....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<...
..<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<
...<<<...<<<....>>>.........<<<<....>>>>....>>>...
.>>...<<<<<.........>>>>>))<<<<.<<<<<<<<...<<<....
>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>
>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>
.....>>>>>....><<<<..........>>>>>>>>...>>>>>>>.>>
>>.........>>>>>>..........>>>>.>>>>>>>>>>>>..>>..
...<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<
<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><
<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<
<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>
>>>>>>...<<<.<<<..<<<<<<.....<<.....<<<<....>>>>..
...>>..>>>>..>>>>><<<<<<.......>>>>>>........<....
.......<<<<<.......>>>>>.....>....>>>....>>.>>>>>>
>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>
>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<
<...<<<<<<<..>>>>>>>...<<<<<.....<<<<...<<<<....>>
>>...............<<<<<<.......>>>>>>..>>>>..>>>>>.
.....>>>.>>>..>>>>>...<<<.....>>>..<<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<
<<....>>>.>>))).......((((((..((((.>>>>>>)))))))))
)..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<..
.....>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.
<.<<<......>>>.>...>>>.<<<.........>>>.....>>>>>..
>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]
....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><
<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..
>>>>>..<<<...<<<<<...........>>>>>...>>>..>>>>....
>>>>>>>....<<<<<<<<<<<<......<<.......<<<<<<<..>>>
>>>>....>>...........<<<...<<<<<<<<<<<......>>>>.>
>>>>>>.>>>..................>>>>>>>>>>>>.<<<<<<<..
...........>.....<<<<<<<<<.<<<....<<<<.<..<<<<<...
...>>>>>..>>>>>...>>>....>>>>...>>>>>..>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ipa Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Resolution3.4 Å
Binding residue
(original residue number in PDB)
V40 T41 F42 H43 R44 S49 K50 R52 D53 P54 K55 Y56 R58 T79 S81 K85 N89 D101 K102 N121 T122 L123 P126 K130 Y133 K135
Binding residue
(residue number reindexed from 1)
V4 T5 F6 H7 R8 S13 K14 R16 D17 P18 K19 Y20 R22 T43 S45 K49 N53 D65 K66 N85 T86 L87 P90 K94 Y97 K99
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8ipa, PDBe:8ipa, PDBj:8ipa
PDBsum8ipa
PubMed38267667
UniProtA0A1D5UQZ5

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