Structure of PDB 8w2o Chain N Binding Site BS01

Receptor Information
>8w2o Chain N (length=91) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIPVKLLNEAQGHIVSLELTTGATYRGKLVESEDSMNVQLRDVIATEPQG
AVTHMDQIFVRGSQIKFIVVPDLLKNAPLFKKNSSRPMPPI
Ligand information
>8w2o Chain R (length=327) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accuuaagauaucagaggaaaguccuacugaucaaacaugcgcuuccaau
aguagaaggacguuaagcauuuaucauugaacuguucauugaagucauug
augcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcu
gacguuuccauucccuuguuucaaucauugguuaaacugauuuuuggggc
ccuuuguuucuucugccuggagaaguuugacaccaaauucaaauuggugu
uaggggagcuggggccuuucaaaaaaauuuuggaaggucuugguaggaac
ggguggaucuuauaauuuuugauuuau
.....<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<<<<...
.....<<<<<.<<<..<<<<.<.<<<.<<<<<.>>>>>.>>>.......>
>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<
<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.>>>>>>>..>>>>>>>
((.......<<<<<....))>>>>>...<<<<<<<<.<....>>>>>>>>
>.>>>>><<<<<<<<<<<<<<<<<...>>>>>>>>>>>>>>>>>.>>>>>
>..>>>.>>>>................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8w2o Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast.
Resolution3.49 Å
Binding residue
(original residue number in PDB)		N41 G54 A55 V56 G66 S67 M92 I95
Binding residue
(residue number reindexed from 1)		N37 G50 A51 V52 G62 S63 M88 I91
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0036261 7-methylguanosine cap hypermethylation
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0005687 U4 snRNP
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034715 pICln-Sm protein complex
GO:0034719 SMN-Sm protein complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071004 U2-type prespliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0097525 spliceosomal snRNP complex
GO:0097526 spliceosomal tri-snRNP complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w2o, PDBe:8w2o, PDBj:8w2o
PDBsum8w2o
PubMed38688558
UniProtP43321|SMD3_YEAST Small nuclear ribonucleoprotein Sm D3 (Gene Name=SMD3)

[Back to BioLiP]