Structure of PDB 8qpe Chain N Binding Site BS01

Receptor Information
>8qpe Chain N (length=831) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLGMPAPLGYVPGLGRGATGFTTRSDIGPAKDDEEADAIYAALDKRMDER
RKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGD
ARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGRNTLMDM
RLSQQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPP
AWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAA
VELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENI
PTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDA
EECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECAR
AIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVL
WLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPK
LWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLT
RARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNS
GILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKA
REWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGE
LWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Ligand information
>8qpe Chain 4 (length=63) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuauugcuaauu
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>...........
Receptor-Ligand Complex Structure
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PDB8qpe Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N168 K169 R172 R175 Y176 E177 K178 P824 Q825 R826 K829
Binding residue
(residue number reindexed from 1)		N103 K104 R107 R110 Y111 E112 K113 P714 Q715 R716 K719
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qpe, PDBe:8qpe, PDBj:8qpe
PDBsum8qpe
PubMed38778104
UniProtO94906|PRP6_HUMAN Pre-mRNA-processing factor 6 (Gene Name=PRPF6)

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