Structure of PDB 8i0s Chain N Binding Site BS01

Receptor Information
>8i0s Chain N (length=143) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIF
RIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENL
CCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCS
Ligand information
>8i0s Chain F (length=97) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu
<<<<<.<......>>>>>>...............................
......<<...<<<.....>>>....>>...................
Receptor-Ligand Complex Structure
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PDB8i0s Molecular Basis for the Activation of Human Spliceosome
Resolution4.2 Å
Binding residue
(original residue number in PDB)		G39 Q95 G96 Y97 E98 T111 N112 T115 N116 C117 I118 H136
Binding residue
(residue number reindexed from 1)		G39 Q95 G96 Y97 E98 T111 N112 T115 N116 C117 I118 H136
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016922 nuclear receptor binding
GO:0030374 nuclear receptor coactivator activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:2000825 positive regulation of androgen receptor activity
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Biological Process
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Cellular Component
External links
PDB RCSB:8i0s, PDBe:8i0s, PDBj:8i0s
PDBsum8i0s
PubMed39068178
UniProtP41223|BUD31_HUMAN Protein BUD31 homolog (Gene Name=BUD31)

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