Structure of PDB 8ch6 Chain N Binding Site BS01

Receptor Information
>8ch6 Chain N (length=791) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDEWERTERERLQDLEERDAFAERVRQRDKDRTMVPELRKKSRREYLAKR
EREKLEDLEAELADEEFLRHERQELKYKRRVRDLAREYRAAGEQEKLEAT
NRYHMPKETRGQPARAVDESGAPGEEQRRWEEARLGAASLKFGARDAASQ
EPKYQLVLEETQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLIIEGE
TGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKL
GNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAH
ERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIP
GRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEA
ACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVA
TNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRA
GRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIH
DLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPM
LSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFL
PGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLE
RVEVGLSSCQGDYIRVRKAITAGYFYHTARYRTVKQQQTVFIHPNSSLFE
QQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAK
Ligand information
>8ch6 Chain g (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucggccuccgaacgguaagagccuagcauguagaacugguuaugauguca
uacuuauccugucccuuuuuuuucca
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Receptor-Ligand Complex Structure
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PDB8ch6 Structural basis of catalytic activation in human splicing.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		R239 P453 R454 R455 R482 T497 D498 G499 M500 R503 L506 S507 H528 T616 G617 Q618 Y648 A649 T674 N675 I676 K696 P819 N850 R856 Q917 R924 H971 P972 N973 F977 E988 T992 K994 F996 R998
Binding residue
(residue number reindexed from 1)		R50 P230 R231 R232 R259 T274 D275 G276 M277 R280 L283 S284 H305 T393 G394 Q395 Y425 A426 T451 N452 I453 K473 P596 N627 R633 Q694 R701 H743 P744 N745 F749 E760 T764 K766 F768 R770
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0038187 pattern recognition receptor activity
GO:0043130 ubiquitin binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045087 innate immune response
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ch6, PDBe:8ch6, PDBj:8ch6
PDBsum8ch6
PubMed37165190
UniProtO60231|DHX16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (Gene Name=DHX16)

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