Structure of PDB 7ttw Chain N Binding Site BS01

Receptor Information
>7ttw Chain N (length=50) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVPKRRTSKTRKNKRRTHFKISVPGMTECPNCGEYKLSHRVCKNCGSYNG
Ligand information
>7ttw Chain 1 (length=2690) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acuucagacaaacuccgaaugccaauuaauuuaacuugggagucagaaca
ugggugauaagguccguguucgaaagggaaacagcccagaccaccagcua
aggucccaaaauauauguuaaguggaaaaggauguggcguugccacagag
ugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugug
gauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcau
gaucguaaggacauguggagcgcuuagaagugagaaugccggugugagua
gcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagag
gaaggcucguccgcucuggguuagucggguccuaagcugaggccgacagg
cguaggcgauggauaacagguugauauuccuguaccaccuauaaucguau
cgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgu
cuaagcaguaaggcugccgguagcugagcugugauggggagaagaccuuc
gagucguugauuucacacugccgagaaaagccucuagauagaaaauaggu
gcccguaccgcaaaccgacacagguagucaagaugagaauucuaagguga
gcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgg
gagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauag
gcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggu
gauguauaggggcugacgccugcccggugcuggaagguuaagaggagugg
uuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaa
cuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccc
gcacgaaaggcguaacgauuugggcacugucucaacgagagacucgguga
aaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagac
cccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccg
caccacuuaucguggugggagacagugucaggcgggcaguuugacugggg
cggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaug
guuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgag
accuacaagucgagcagggucgaaagacggacuuagugauccggugguuc
cgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaaca
ggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucga
ugucggcucaucgcauccuggggcuguagucggucccaaggguugggcug
uucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacag
uucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuu
aguacgagaggaccgggauggacauaccucugguguaccaguugucgugc
caacggcauagcuggguagcuauguguggacgggauaagugcugaaagca
ucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaa
gaucccucaaagaugaugagguuaauagguucgagguggaagcaugguga
cauguggagcugacgaauacuaaucgaucgaagacuuaau
<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<......
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>........>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<.>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<
<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<.<.<<........
>>.>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>
><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<
<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......
<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>
>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<
<...<<<<....<<<<...<<...<....<.<<<.........>>>.>.<
....<<<<...<<<........>>>...>>>>.....>.....<....>.
.......>....>>...>>>>.........>>>>..>>......>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>.
.<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>
.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>
.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<
<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<<.....>>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>..
...>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......
<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<..>.>>>>....<<.
<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<....
.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<
<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.(
(..>>>>..))>>>>>>>.............>>>>..]]>>>>.......
<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.....
..<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<..
...>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>
>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.
..............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<...
...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<.......
....>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....
<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....
>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..
Receptor-Ligand Complex Structure
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PDB7ttw A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
A2 V3 P4 K5 R6 R7 S9 K10 T11 R12 K13 K15 R16 R17 T18 H19 H40 R41 Y49 N50 G51
Binding residue
(residue number reindexed from 1)
A1 V2 P3 K4 R5 R6 S8 K9 T10 R11 K12 K14 R15 R16 T17 H18 H39 R40 Y48 N49 G50
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7ttw, PDBe:7ttw, PDBj:7ttw
PDBsum7ttw
PubMed35736238
UniProtQ2FZF1|RL32_STAA8 Large ribosomal subunit protein bL32 (Gene Name=rpmF)

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