Structure of PDB 7pfx Chain N Binding Site BS01

Receptor Information
>7pfx Chain N (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASR
LAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA
Ligand information
>7pfx Chain I (length=177) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccgccactggccactggagaatcccggtgccgaggccgctcaattggt
cgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcg
ttttaaccgccaaggggattactccctagtctccaggcacgtgtcacata
tatacatcctgtgcatgtaagtgcatg
Receptor-Ligand Complex Structure
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PDB7pfx Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R31 R33 K34 S36 Y40
Binding residue
(residue number reindexed from 1)		R2 R4 K5 S7 Y11
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0019731 antibacterial humoral response
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfx, PDBe:7pfx, PDBj:7pfx
PDBsum7pfx
PubMed35581345
UniProtO60814|H2B1K_HUMAN Histone H2B type 1-K (Gene Name=H2BC12)

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