Structure of PDB 7of6 Chain N Binding Site BS01

Receptor Information

>7of6 Chain N (length=205) Species: 9606 (Homo sapiens)

KPKLRFIERAPLVPKVRREPKNLSDIRGPSTEATEFTEGNFAILALGGGY
LHWGHFEMMRLTINRSMDPKNMFAIWRVPAPFKPITRKSVGHRMGGGKGA
IDHYVTPVKAGRLVVEMGGRCEFEEVQGFLDQVAHKLPFAAKAVSRGTLE
KMRKDQEERERNNQNPWTFERIATANMLGIRKVLSPYDLTHKGKYWGKFY
MPKRV

Ligand information

>7of6 Chain A (length=1463)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacgu
uuaacggccgcgguaccgugcaaagguagcauaaucacuuguuccuuaaa
uagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuu
aaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaaga
cgagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaa
aaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguac
augcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuug
accaacggaacaaguuacccuagggauaacagcgcaauccuauucuagag
uccauaucaacaauaggguuuacgaccucgauguuggaucaggacauccc
gauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccua
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
aauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaag
cgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacc
caagaacaggguu

<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<..<<<<<..>>
>..>>>>><<<<<..>>>>>........<...........<<<<<<....
.>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>
>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<
.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
..<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>
............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.
......>>...>>>>>>...>.>>.>.........<<<.<<<<<<..<<.
<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>.
.>...>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>..
.<<<.<<<.................>>>.>>><<<<<...<<<....>>>
.>>>>>......<<<................>>>.............<<<
<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of6 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): R63 R64 P66 K67 N68 L69 S70 R73 Y96 G100 H101 M104 R111 R133 K134 R139 M140 G141 G142 G143 K144 Q178 K182 L183 P184 R227 K228 V229 L230 S231 P232 Y233 K244
• Binding residue (residue number reindexed from 1): R17 R18 P20 K21 N22 L23 S24 R27 Y50 G54 H55 M58 R65 R87 K88 R93 M94 G95 G96 G97 K98 Q132 K136 L137 P138 R181 K182 V183 L184 S185 P186 Y187 K198

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of6, PDBe:7of6, PDBj:7of6
• PDBsum: 7of6
• PubMed: 34135319
• UniProt: Q9NX20|RM16_HUMAN Large ribosomal subunit protein uL16m (Gene Name=MRPL16)