Structure of PDB 6zku Chain N Binding Site BS01

Receptor Information

>6zku Chain N (length=347) Species: 9940 (Ovis aries)

MNPIILIIILMTVMLGTIIVMISTHWLLIWIGFEMNMLAIIPIMMKKHNP
RATEASTKYFLTQSTASMLLMMAIIINLMFSGQWTVMKLFNPMASMLMTM
ALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQILPSIN
LDLILTLSILSITIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLLYNPTM
TLLNLIIYIIMTSTMFTLFMANSTTTTLSLSHTWNKAPIMTILVLITLLS
MGGLPPLSGFMPKWMIIQEMTKNDSIILPTLMAITALLNLYFYMRLTYST
ALTMFPSTNNMKMKWQFPTTKRMTLLPTMTVLSTMLLPLTPILSILE

Ligand information

>6zku Chain V (length=19) Species: 9940 (Ovis aries)

ALVKMGQLEGWKVFAEPKV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zku The coupling mechanism of mammalian respiratory complex I.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): L151 D152 Y196 N273 I277 L278
• Binding residue (residue number reindexed from 1): L151 D152 Y196 N273 I277 L278

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:0072593 reactive oxygen species metabolic process
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:6zku, PDBe:6zku, PDBj:6zku
• PDBsum: 6zku
• PubMed: 32972993
• UniProt: O78748|NU2M_SHEEP NADH-ubiquinone oxidoreductase chain 2 (Gene Name=MT-ND2)