Structure of PDB 6wc2 Chain N Binding Site BS01

Receptor Information

>6wc2 Chain N (length=53) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRY
KSK

Ligand information

>6wc2 Chain E (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aagcactttcttaaaatagtg

Receptor-Ligand Complex Structure

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PDB	6wc2 Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	R142 Y162 R168 Q187 Y191
Binding residue (residue number reindexed from 1)	R1 Y21 R27 Q46 Y50

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677	DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:6wc2, PDBe:6wc2, PDBj:6wc2
PDBsum	6wc2
PubMed	32681840
UniProt	P52952\|NKX25_HUMAN Homeobox protein Nkx-2.5 (Gene Name=NKX2-5)

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