Structure of PDB 6ven Chain N Binding Site BS01

Receptor Information
>6ven Chain N (length=218) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINVS
SSRDNRASNRRFQQDIEAQKAAILLSLNQLNKRKKPVMFARSAIHNWGLY
ALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVI
DATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYD
YKFEPCLCGAPNCKGFLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ven Chain N Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ven Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome.
Resolution3.37 Å
Binding residue
(original residue number in PDB)		C1068 C1070 K1076
Binding residue
(residue number reindexed from 1)		C206 C208 K214
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0042800 histone H3K4 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6ven, PDBe:6ven, PDBj:6ven
PDBsum6ven
PubMed31922488
UniProtP38827|SET1_YEAST Histone-lysine N-methyltransferase, H3 lysine-4 specific (Gene Name=SET1)

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