Structure of PDB 6tm5 Chain N Binding Site BS01

Receptor Information
>6tm5 Chain N (length=676) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPGQELLVAWNTVSTGLVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQ
NDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLESRLDPYLRSLE
LLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGWCRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLHQVTR
ERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFNTLRRWRCHVQRFFYR
IYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALET
RLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDT
VRQIVAGLTSGEPEDWVPDPVDSDIISLLVSIYGSKDLFINEYRSLLADR
LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIRE
EDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKY
EQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASW
TLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDN
MVLIKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDL
QELQGYLQKKVRDQQLVYSAGVYRLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6tm5 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		N392 D395 Q806
Binding residue
(residue number reindexed from 1)		N308 D311 Q664
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0007399 nervous system development
GO:0010629 negative regulation of gene expression
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031915 positive regulation of synaptic plasticity
GO:0045773 positive regulation of axon extension
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0090129 positive regulation of synapse maturation
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tm5, PDBe:6tm5, PDBj:6tm5
PDBsum6tm5
PubMed32307883
UniProtQ9UJX6|ANC2_HUMAN Anaphase-promoting complex subunit 2 (Gene Name=ANAPC2)

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