Structure of PDB 6qg6 Chain N Binding Site BS01

Receptor Information
>6qg6 Chain N (length=408) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFLERNITIKLGYANAK
IYKCQESFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLS
GAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMRE
ESALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPP
RDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIR
PGIVTKDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLC
RADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKKQAKVRKLEPNEV
LMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRL
IGWATIKK
Ligand information
>6qg6 Chain P (length=17) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VGLPYSELLSRFFNILR
Receptor-Ligand Complex Structure
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PDB6qg6 Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Resolution10.4 Å
Binding residue
(original residue number in PDB)		K165 Q248 E256 Q263 I280 P282 S284 L287 N290
Binding residue
(residue number reindexed from 1)		K59 Q142 E150 Q157 I174 P176 S178 L181 N184
Enzymatic activity
Catalytic site (original residue number in PDB) A110 K113 S114 T137 H197
Catalytic site (residue number reindexed from 1) A17 K20 S21 T41 H91
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0031369 translation initiation factor binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6qg6, PDBe:6qg6, PDBj:6qg6
PDBsum6qg6
PubMed31201334
UniProtP32481|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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