Structure of PDB 6exn Chain N Binding Site BS01

Receptor Information

>6exn Chain N (length=242) Species: 559292 (Saccharomyces cerevisiae S288C)

EPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSNNII
KTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEEAKN
DMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLRKSFFLYNIDAS
IPEWKITDTVSQLLGILSLIVNHKAKCGGLRFQSSELGERFVSKIRGVLL
IDRFRIFIIPWSSGFSAASFGTNTAENIKLSLSLNKLIQLEL

Ligand information

>6exn Chain 6 (length=102)

guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacag
agaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagau
uu

<<<<<<<<<<.....>>>>>>>>>>.........................
............<<<..<<<.....>>>...>>>................
..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6exn Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): I28 G31 K47 K50 R51 N53 I55 K57 M108
• Binding residue (residue number reindexed from 1): I22 G25 K41 K44 R45 N47 I49 K51 M102

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0017070 U6 snRNA binding
• GO:0036002 pre-mRNA binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing

Cellular Component

• GO:0000974 Prp19 complex
• GO:0005634 nucleus
• GO:0005681 spliceosomal complex
• GO:0071006 U2-type catalytic step 1 spliceosome
• GO:0071007 U2-type catalytic step 2 spliceosome

External links

• PDB: RCSB:6exn, PDBe:6exn, PDBj:6exn
• PDBsum: 6exn
• PubMed: 29146871
• UniProt: P38241|SLT11_YEAST Pre-mRNA-splicing factor SLT11 (Gene Name=ECM2)