Structure of PDB 5z3g Chain N Binding Site BS01

Receptor Information
>5z3g Chain N (length=226) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATRTQFENSNEIGVFSKLTNTYCLVAVGGSENFYSAFEAELGDAIPIVH
TTIAGTRIIGRMTAGNRRGLLVPTQTTDQELQHLRNSLPDSVKIQRVEER
LSALGNVICCNDYVALVHPDIDRETEELISDVLGVEVFRQTISGNILVGS
YCSLSNQGGLVHPQTSVQDQEELSSLLQVPLVAGTVNRGSSVVGAGMVVN
DYLAVTGLDTTAPELSVIESIFRLQD
Ligand information
>5z3g Chain A (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaau
aagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaa
gcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguugua
auuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaac
aggacgucauagagggugagaaucccguguggcgaggagugcgguucuuu
guaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugg
guggccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguac
agugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgug
aaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccu
cugcuccuuguggguaggggacgcauuucacugggccagcaucaguuuug
guggcaggauaaauccauaggaauguagcuugccucgguaaguauuauag
ccugugggaauacugccagcugggacugaggacugcgacguaagucaagg
augcuggcauaaugguuauaugccgcccgucuugaaacacggaccaagga
gucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaagguu
ggggccucgcaagaggugcacaaucgaccgauccggauuugaguaagagc
auagcuguugggacccgaaagauggugaccaucuaguagcugguuccugc
cgaaguuucccucaggauagcagaagcucguaucaguuuuaugguaagga
augaagagcuuuuagugggccauuuuuggagaacuggcgaugcgggauga
accgaacguagaguuaaggugccggaauacacgcucacaaaagguguuag
uucaucugaacuagcccugggcgcucaagcguguuaccuauacucuaccg
ucaggguugauaugaugcccugacgaguaggcaggcguggaggucaguga
cgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuug
gugguaguagcuagaucuagcgaaaccacagccaaggcuuggguuaccgc
aauaguaauugaacuuaguacgagaggaacaguucauucggauaauuggu
uuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggau
uauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcu
ccacacaaagauggauacgaauaaggcguccuuguggcgucgcugaacca
uagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcug
gcgaauugcaaugucagcguggggauaaaucauuuguauacgacuuagau
guacaacgggguauuguaagcgcugagauuaagccuuuguugucugauuu
g
..........................<<<<<<.....<......>.....
.>>>>>.>.........<<....>>..<<<<<......<<.....>>...
..>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>......
..>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......
>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>..
..>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<
<<<..>>>>>..>>>..................................<
<....>>...............<<<......>>>................
..................<<<<<.<<<<<<.....<<<<...<<<..<<<
<<<<<.......>>>>>>>>..>>>...>>>>..<<<<<<<.<<<<<<<<
<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......
>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....
.>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<..
...<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>....<<<<
<..<<<<<....>>>>>...>>>>>.<<....<..>......>>....>>
>>>>.>>>>>...<<.<...<<<<<<.>>>>>>......>.>>..<<<<<
<......<<<....>>>..<<<<<<<<.....<<<.<<<<<<.>>>>..>
>>>>...>>>>>>.>>..<<<<.<<<....>>>.>>>>....<<<.....
.>>>...<<<<<<<..<<<<(((.....<<<<<<.......<<<.<<<<<
<<<<..>>>>>>>>>>>>.)))......>>>>>>.>>>>..>>>>>>><<
<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<..
....<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>
>><<.....<<<<<..>>>>>....>>....<<<<<.>>>>>.<<<<<<<
..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<
....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<.
..<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..<<
<<<<........<<..........<<<<<<.....>>>>>>......>>.
......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>
>>................>>>>>>.<<<<<<.<..<.......>..>...
..<<<<<.<<<.<<.....<..>....>>....>>>..>>>>>..>>>>>
>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5z3g Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		Q6 E8 G30
Binding residue
(residue number reindexed from 1)		Q6 E8 G30
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0000460 maturation of 5.8S rRNA
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 maturation of LSU-rRNA
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0042254 ribosome biogenesis
GO:0042256 cytosolic ribosome assembly
GO:0042273 ribosomal large subunit biogenesis
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030687 preribosome, large subunit precursor

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5z3g, PDBe:5z3g, PDBj:5z3g
PDBsum5z3g
PubMed29557065
UniProtQ12522|IF6_YEAST Eukaryotic translation initiation factor 6 (Gene Name=TIF6)

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