Structure of PDB 5x4z Chain N Binding Site BS01

Receptor Information
>5x4z Chain N (length=1074) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIIRFG
KIYLSRPTMTEADGTTHAMFPQEARLRNLTYSSPVYLDMEKKVHIGKVPI
MLRSKFCSLRTLDEVDLYKMKECPYDMGGYFVINGSEKVLIAQESAANIV
QVFKKAAPSPISHVAEIRSALEKGSRLISTMQIKLYGREDKGRTIKATLP
YVKQDIPIVIVFRALGVVPDGEILQHICYDENDWQMLEMLKPCIEEGFVI
QDKEVALDFIGEKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNR
LLLCALERKDQDDRDHFGKKLDLAGPLLANLFRILFRKLTREIYRYMQRC
IELAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLS
HLRRTNTPIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLSGISIGS
PSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDPSMLVST
MRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDDESKDNE
LRITKEHIRKIVYGWSSLVTSGVIEYVDGEEEETIMIAMTPEDLDTAKRI
KPTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTN
YNVRMDTMANILYYPQKPLAKTQAMEYLKFRELPAGQNAIVAIACYSGYN
QEDSMIMNQSSIDRGLFRSLFFRSYMDQEKRFGISIVEEFEKPTRATTLR
LKHGTYEKLDEDGLIAPGVRVSGDDIIIGKTTPIKRDASTPLRSTENGIV
DQVLLTTNQEGLKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDM
PFSAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTD
LTVDAVSNLLRDNGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMV
DDKIHARARGPVQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKE
LMEASDAFRVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAA
KLLFQELMAMNIAPRLYTERSGVS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5x4z Chain N Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5x4z Crystal structure of RNA polymerase II from Komagataella pastoris
Resolution7.8 Å
Binding residue
(original residue number in PDB)		C1166 C1185
Binding residue
(residue number reindexed from 1)		C1016 C1035
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5x4z, PDBe:5x4z, PDBj:5x4z
PDBsum5x4z
PubMed28412353
UniProtC4QZQ7

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