Structure of PDB 5m0r Chain N Binding Site BS01

Receptor Information

>5m0r Chain N (length=266) Species: 36374 (Visna/maedi virus EV1 KV1772) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NIPLAEEEHNKWHQDAVSLHLEFGIPRTAAEDIVQQCDVCQENKKRGIDH
WQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFRVQTMKWYAMFAP
KSLQSDNGPAFVAESTQLLMKYLGIEHTTGIPWNPQSQALVERTHQTLKN
TLEKLIPMFNAFESALAGTLITLNIKRKGGLGTSPMDIFIFNKEQQRIQQ
QSKSKQEKIRFCYYRTRKRGHPGEWQGPTQVLWGGDGAIVVKDRGTDRYL
VIANKDVKFIPPPKEI

Ligand information

>5m0r Chain Q (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gctgcgagatccgctccggtg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5m0r A supramolecular assembly mediates lentiviral DNA integration.
Resolution	8.2 Å
Binding residue (original residue number in PDB)	W245 V252
Binding residue (residue number reindexed from 1)	W233 V240

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding

	Biological Process
GO:0015074	DNA integration

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Molecular Function

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Biological Process

External links

PDB	RCSB:5m0r, PDBe:5m0r, PDBj:5m0r
PDBsum	5m0r
PubMed	28059770
UniProt	P35956\|POL_VILVK Gag-Pol polyprotein (Gene Name=pol)

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