Structure of PDB 5lf0 Chain N Binding Site BS01
Receptor Information
>5lf0 Chain N (length=202) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
TTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAA
DTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIII
AGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKE
ECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVA
TL
Ligand information
>5lf0 Chain e (length=4) Species:
32630
(synthetic construct) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
IITg
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
5lf0
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Resolution
2.41 Å
Binding residue
(original residue number in PDB)
T1 T20 T21 T22 R45 G47 A49 S169
Binding residue
(residue number reindexed from 1)
T1 T20 T21 T22 R45 G47 A49 S169
Enzymatic activity
Catalytic site (original residue number in PDB)
T1 D17 R19 K33 G47 S130 D167 S170
Catalytic site (residue number reindexed from 1)
T1 D17 R19 K33 G47 S130 D167 S170
Enzyme Commision number
3.4.25.1
: proteasome endopeptidase complex.
Gene Ontology
Molecular Function
GO:0004298
threonine-type endopeptidase activity
Biological Process
GO:0051603
proteolysis involved in protein catabolic process
Cellular Component
GO:0005839
proteasome core complex
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:5lf0
,
PDBe:5lf0
,
PDBj:5lf0
PDBsum
5lf0
PubMed
27493187
UniProt
P28072
|PSB6_HUMAN Proteasome subunit beta type-6 (Gene Name=PSMB6)
[
Back to BioLiP
]